Lactamases and Resistance to Penicillins and Cephalosporins in Serratia marcescens
| Autor: | Farrar We, Noel M. O'Dell |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.drug_class
Klebsiella pneumoniae Penicillin Resistance medicine.medical_treatment Cephalosporin Penicillins medicine.disease_cause Amidohydrolases Microbiology Osmotic Pressure polycyclic compounds medicine Immunology and Allergy Escherichia coli Beta-Lactamase Inhibitors Serratia marcescens Cephalosporinase biology Chemistry Penicillinase Carbenicillin biology.organism_classification Cephalosporins Penicillin Infectious Diseases Beta-lactamase Ampicillin beta-Lactamase Inhibitors Chloromercuribenzoates Cloxacillin Plasmids medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 134:245-251 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/134.3.245 |
| Popis: | Strains of Serratia marcescens fall into one of two groups with respect to their resistance to to beta-lactum antibiotics. Most strains are highly resistant to cephalosporins but are significantly more susceptible to ampicillin and carbenicillin, whereas other strains are highly resistant to both penicillins and cephalosporins. Strains in the former category produce small amounts of an inducible cephalosporinase, which appears to be chromosomally mediated. Strains in the latter class also elaborate large amounts of a noninducible penicillinase-cephalosporinase, which is plasmidmediated. Ability to produce this type of enzyme can be transferred to Klebsiella pneumoniae or Escherichia coli and may be lost spontaneously or after exposure of S. marcescens to "curing" agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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