Activity of the investigational fluoroquinolone finafloxacin and seven other antimicrobial agents against 114 obligately anaerobic bacteria
| Autor: | W. Stubbings, Reiner Schaumann, Gelimer H. Genzel, H. Labischinski, Catalina Suzana Stingu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
biology Chemistry Broth microdilution Microbial Sensitivity Tests General Medicine biology.organism_classification Tazobactam Microbiology Bacteria Anaerobic Minimum inhibitory concentration Finafloxacin chemistry.chemical_compound Infectious Diseases Anti-Infective Agents Moxifloxacin medicine Pharmacology (medical) Anaerobic bacteria Bacteroides fragilis Fluoroquinolones medicine.drug Piperacillin |
| Zdroj: | International Journal of Antimicrobial Agents. 44:420-423 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2014.07.006 |
| Popis: | The activity of finafloxacin against 73 strains of the Bacteroides fragilis group, 10 other Gram-negative anaerobic rods and 31 Clostridium difficile strains was determined by the broth microdilution technique. The activity was compared with that of moxifloxacin, levofloxacin, ciprofloxacin, clindamycin, imipenem, piperacillin/tazobactam and metronidazole. MIC(50/90) values (minimum inhibitory concentration, in μg/mL, at which 50% and 90% of the isolates tested are inhibited, respectively) for finafloxacin for the different species were determined: B. fragilis group, 0.5/2; other Gram-negative rods, 0.06/0.25; and C. difficile, 4/16. Furthermore, the MICs against 11 selected B. fragilis strains were determined under acidic conditions and resulted in MIC(50/90) values for finafloxacin of 0.25/4 μg/mL. Thus, finafloxacin shows promising activity against several pathogenic species of anaerobes. Furthermore, finafloxacin has increased activity against selected B. fragilis strains under acidic conditions compared with activity at neutral pH. |
| Databáze: | OpenAIRE |
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