Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma

Autor: Hongyan Guo, Bi-bo Yuan, Jun Hu, Cong-jian Xu, Cai-ling Ma, Zhi-qing Liang, Yuan-guang Meng, Peng Peng Qu, Li-rong Zhu
Rok vydání: 2011
Předmět:
Oncology
Adult
medicine.medical_specialty
endocrine system diseases
media_common.quotation_subject
Fertility
Ovary
Carcinoma
Ovarian Epithelial
General Biochemistry
Genetics and Molecular Biology
Disease-Free Survival
Fertility sparing surgery
Young Adult
Risk Factors
Internal medicine
medicine
Humans
Fertility preservation
Neoplasms
Glandular and Epithelial
General Pharmacology
Toxicology and Pharmaceutics
Young adult
media_common
Neoplasm Staging
Retrospective Studies
Gynecology
Ovarian Neoplasms
Pregnancy
General Veterinary
integumentary system
business.industry
Fertility Preservation
Retrospective cohort study
General Medicine
medicine.disease
Prognosis
female genital diseases and pregnancy complications
Biomedicine
medicine.anatomical_structure
Epithelial ovarian carcinoma
Female
Neoplasm Recurrence
Local
business
Zdroj: Journal of Zhejiang University. Science. B. 12(10)
ISSN: 1862-1783
Popis: Objective: To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC). Methods: A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions. Results: Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups. Conclusions: Fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.
Databáze: OpenAIRE
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