Single shot tetanus vaccine manufactured by a supercritical fluid encapsulation technology
| Autor: | Andrew L. Lewis, Lindy G. Durrant, Andrew Naylor, O.R. Davies, Lisbeth Illum, H.M. Woods, Aj. Baxendale, Ian Spendlove, M.J. Whitaker, P. van Hooff, Steven M. Howdle |
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| Rok vydání: | 2011 |
| Předmět: |
Polymers
Drug Compounding Polyesters Pharmaceutical Science complex mixtures Drug Administration Schedule Placebos Mice chemistry.chemical_compound Drug Delivery Systems Adjuvants Immunologic Antigen Tetanus Toxoid medicine Animals Lactic Acid Particle Size Microparticle Drug Carriers Mice Inbred BALB C Vaccines Tetanus Chromatography Dose-Response Relationship Drug Chemistry Alum Toxoid Single shot medicine.disease Control Groups Supercritical fluid Tetanus vaccine Delayed-Action Preparations Immunology Alum Compounds Female Immunization medicine.drug |
| Zdroj: | International Journal of Pharmaceutics. 413:147-154 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2011.04.053 |
| Popis: | Single shot vaccines of tetanus toxoid (TT) were manufactured using the NanoMix™ process – a low temperature solvent free encapsulation technology using supercritical fluids. The formulations were injected into mice, and compared to multiple injections of a commercially available alum adsorbed TT vaccine. After 5 months the antibody titres were found to be similar for both the alum adsorbed and microparticle formulations, demonstrating for the first time the potential of formulating antigens in PLA microparticles using the supercritical fluid (NanoMix™) technique to produce single shot vaccines. The results are likely to be due to the maintenance of toxoid bioactivity and some degree of sustained release of the encapsulated antigens, resulting in repeated stimulation of antigen presenting cells eliminating the need for multiple immunisations. This demonstrates the potential of this supercritical fluid processing technique to reduce the need for booster doses in a vaccine regimen. |
| Databáze: | OpenAIRE |
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