Effect of L-carnitine treatment on very low density lipoprotein kinetics in the hyperlipidemic rabbit
| Autor: | A.K.M. Jalaluddin Bhuiyan, David William Foster, Leighton James, David W. Seccombe |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Glycerol
Male Very low-density lipoprotein medicine.medical_specialty Clinical Biochemistry Kinetics Hyperlipidemias Lipoproteins VLDL digestive system chemistry.chemical_compound Animal model Carnitine Internal medicine polycyclic compounds medicine Animals Triglycerides Apolipoproteins B Catabolism Cholesterol nutritional and metabolic diseases General Medicine Dietary Fats Endocrinology chemistry lipids (amino acids peptides and proteins) Rabbits Corn oil medicine.drug |
| Zdroj: | Clinical Biochemistry. 28:451-458 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/0009-9120(95)00026-6 |
| Popis: | This study examined the hypolipidemic effect of 4 weeks of L-carnitine treatment (170 mg/kg b.w./day) in New Zealand White rabbits fed a high fat diet (5% corn oil/0.5% cholesterol). Specifically, [3H] glycerol and [125I] very low density lipoprotein (VLDL) turnover studies were conducted to examine the effect of treatment on VLDL kinetics. The masses of plasma VLDL-triglycerides (VLDL-TG) and VLDL-apoprotein B (VLDL-apoB) were significantly increased by the high-fat diet. Four weeks of treatment with L-carnitine significantly reduced these masses. Kinetic analysis indicated that fat feeding reduced the fractional catabolic rates (FCRs) of VLDL-TG and VLDL-apoB relative to chow-fed controls. The transport of these VLDL components was not altered by the diet. L-carnitine treatment had no effect on the FCRs of VLDL-TG and VLDL-apoB or on the transport of VLDL-apoB. Yet, treatment significantly lowered the transport of VLDL-TG. These data indicate that the lipid-lowering effect of L-carnitine in this animal model was due, in part, to a decrease in the transport and not due to an alteration in the fractional catabolic rate of VLDL-TG. |
| Databáze: | OpenAIRE |
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