A versatile and straightforward process to turn plastics into antibacterial materials
| Autor: | Didier Gigmes, Guilherme Machado, Catherine Lefay, Slim Hadiouch, Aurelien Maurel-Pantel, Sabrina Frik, Johanna Saunier, Ariane Deniset-Besseau, Christopher Barner-Kowollik, Lukas Michalek, Najet Yagoubi, Marc Maresca, Yohann Guillaneuf |
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| Přispěvatelé: | Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Groupe matériaux et santé, Université Paris-Saclay, Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Queensland University of Technology [Brisbane] (QUT), Soft Matter Materials Laboratory, School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Physique (ICP), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
Polymers and Plastics Bioengineering 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Biochemistry [SPI.MAT]Engineering Sciences [physics]/Materials [SPI]Engineering Sciences [physics] Amphiphile [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] Copolymer [CHIM]Chemical Sciences Chemistry Organic Chemistry Cationic polymerization 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences HaCaT Membrane [CHIM.POLY]Chemical Sciences/Polymers Extrusion 0210 nano-technology Antibacterial activity ddc:600 |
| Zdroj: | Polymer Chemistry Polymer Chemistry, Royal Society of Chemistry-RSC, 2021, ⟨10.1039/D1PY01344K⟩ Polymer Chemistry, Royal Society of Chemistry-RSC, 2021, 13 (1), pp.69-79. ⟨10.1039/D1PY01344K⟩ Polymer Chemistry, 2022, ⟨10.1039/D1PY01344K⟩ Polymer Chemistry, 13 (1), 69–79 |
| ISSN: | 1759-9954 1759-9962 |
| Popis: | International audience; We demonstrate that antibacterial activity can be conferred to common plastic materials using amphiphilic cationic methacrylate-based block copolymers, specifically quaternized poly(butyl methacrylate)-b-poly(N,N-dimethyl-aminoethyl methacrylate) (PBMA-b-PDMAEMA) with 64 mol% of DMAEMA and Mn close to 20 000 g mol−1. With 0.5–2 wt% of these copolymers simply dispersed in the given matrix by extrusion, the modified materials prove to be active against E. coli, S. aureus, Listeria monocytogenes and enterohemorrhagic E. coli without toxicity against two cell lines, HaCaT and L929 fibroblasts, while keeping the mechanical properties of the materials intact. In addition, the study of the mechanism of action shows that the antibacterial materials target the bacterial membrane, which is expected to avoid antibacterial resistance. Our protocol is a cost-effective solution to generate antibacterial materials for several applications, including packaging or medical devices, without modification of the production process. |
| Databáze: | OpenAIRE |
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