| Autor: |
Josué Llamas-Rodríguez, Jan Oltmer, Douglas N. Greve, Emily Williams, Natalya Slepneva, Ruopeng Wang, Samantha Champion, Melanie Lang-Orsini, Bruce Fischl, Matthew P. Frosch, André J.W. van der Kouwe, Jean C. Augustinack |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's disease : JAD. 87(3) |
| ISSN: |
1875-8908 |
| Popis: |
Background: Neurofibrillary tangle (NFT) accumulation in the entorhinal cortex (EC) precedes the transformation from cognitive controls to mild cognitive impairment and Alzheimer’s disease (AD). While tauopathy has been described in the EC before, the order and degree to which the individual subfields within the EC are engulfed by NFTs in aging and the preclinical AD stage is unknown. Objective: We aimed to investigate substructures within the EC to map the populations of cortical neurons most vulnerable to tau pathology in aging and the preclinical AD stage. Methods: We characterized phosphorylated tau (CP13) in 10 cases at eight well-defined anterior-posterior levels and assessed NFT density within the eight entorhinal subfields (described by Insausti and colleagues) at the preclinical stages of AD. We validated with immunohistochemistry and labeled the NFT density ratings on ex vivo MRIs. We measured subfield cortical thickness and reconstructed the labels as three-dimensional isosurfaces, resulting in anatomically comprehensive, histopathologically validated tau “heat maps.” Results: We found the lateral EC subfields ELc, ECL, and ECs (lateral portion) to have the highest tau density in semi-quantitative scores and quantitative measurements. We observed significant stepwise higher tau from anterior to posterior levels (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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