Episodic memory impairments in bipolar disorder are associated with functional and structural brain changes
| Autor: | Richard Feddern, Viola Oertel-Knöchel, David Edmund Johannes Linden, David Prvulovic, Christian Knöchel, Johannes Pantel, Britta Reinke, Annika Knake |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Bipolar Disorder Memory Episodic Precuneus Neuropsychological Tests computer.software_genre behavioral disciplines and activities Cuneus Young Adult Voxel Neural Pathways Image Processing Computer-Assisted medicine Humans Bipolar disorder Episodic memory Biological Psychiatry Psychiatric Status Rating Scales Memory Disorders medicine.diagnostic_test Neuropsychology Brain Middle Aged medicine.disease Magnetic Resonance Imaging Oxygen Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure nervous system Case-Control Studies Female Functional magnetic resonance imaging Psychology computer Neuroscience Photic Stimulation psychological phenomena and processes Diffusion MRI |
| Zdroj: | Bipolar Disorders. 16:830-845 |
| ISSN: | 1398-5647 |
| Popis: | OBJECTIVES: We combined multimodal functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging to probe abnormalities in brain circuits underpinning episodic memory performance deficits in patients with bipolar disorder (BD). METHODS: We acquired whole-brain fMRI data in 21 patients with BD and a matched group of 20 healthy controls during a non-verbal episodic memory task, using abstract shapes. We also examined density of gray matter, using voxel-based morphometry (VBM), and integrity of connecting fiber tracts, using diffusion tensor imaging (DTI) and tract-based spatial statistics, for areas with significant activation differences. RESULTS: Patients with BD remembered less well than controls which shapes they had seen and had lower activation levels during the encoding stage of the task in the anterior cingulate gyrus, the precuneus/cuneus bilaterally, and the left lingual gyrus, and higher activation levels during the retrieval stage in the left temporo-parietal junction. Patients with BD showed reduced gray matter volumes in the left anterior cingulate, the precuneus/cuneus bilaterally, and the left temporo-parietal region in comparison with controls. DTI revealed increased radial, axial, and mean diffusivity in the left superior longitudinal fascicle in patients with BD compared with controls. CONCLUSIONS: Changes in task-related activation in frontal and parietal areas were associated with poorer episodic memory in patients with BD. Compared with data from single imaging modalities, integration of multimodal neuroimaging data enables the building of more complete neuropsychological models of mental disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |