Electrophysiologic study of HIV-1 + patients without signs of peripheral neuropathy
| Autor: | Massimo Di Pietro, Mecocci Lorenzo, Antonello Grippo, Francesco Lolli, Mazzotta F, O. Ronchi, Paola Ghidini |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Nervous system Pathology medicine.medical_specialty Neural Conduction Action Potentials HIV Infections Sural nerve Asymptomatic Nerve conduction velocity medicine Humans Peripheral Nerves Subclinical infection Analysis of Variance Electromyography business.industry Muscles medicine.disease Median nerve medicine.anatomical_structure Peripheral neuropathy Neurology Peripheral nervous system HIV-1 Female Neurology (clinical) medicine.symptom business |
| Zdroj: | Journal of the Neurological Sciences. 113:209-213 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/0022-510x(92)90248-j |
| Popis: | HIV-1 seropositive patients have a high frequency of nervous system diseases, and asymptomatic abnormalities are frequently detected. We studied 124 neurologically asymptomatic HIV-1 seropositive subjects and 23 normal control subjects by nerve conduction studies. No alterations were detectable in the asymptomatic stages of infection (CDC groups II and III), while subclinical peripheral nervous system (PNS) impairment was detected in symptomatic HIV-1 stages (CDC group IV). Specifically, in CDC group IV we observed a reduction in the motor conduction velocity of the deep peroneal nerve and the median nerve, and a similar reduction of the sensory conduction velocity of the sural nerve. There were no differences of the amplitude and area of the muscular response or of the sensory nerve action potential. As our patients did not present clinical or laboratory evidence for a toxic-dismetabolic etiology, our data indicate a progressive myelin damage more directly related to HIV-1 infection. This subclinical finding may have importance for the progression of the disease in the PNS. |
| Databáze: | OpenAIRE |
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