Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS

Autor:	Wei Yang, Zev J. Greenberg, Molly Romine, Darlene Monlish, Peter D. Aplan, Laura G. Schuettpelz, Sima T. Bhatt, Eric J. Duncavage, John L. Keller, Matthew J. Walter
Rok vydání:	2018
Předmět:	0301 basic medicine Oncogene Proteins Fusion Immunology Biochemistry Mice 03 medical and health sciences medicine Animals Letter to Blood Homeodomain Proteins Ineffective Hematopoiesis High rate Toll-like receptor business.industry Myelodysplastic syndromes Hematopoietic stem cell Cell Biology Hematology medicine.disease Toll-Like Receptor 2 Nuclear Pore Complex Proteins Transplantation Disease Models Animal Cell Transformation Neoplastic 030104 developmental biology medicine.anatomical_structure HOXD13 Myelodysplastic Syndromes Cancer research Stem cell business Transcription Factors
Zdroj:	Blood. 131:1032-1035
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood-2017-08-801944
Popis:	TO THE EDITOR: Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders characterized by ineffective hematopoiesis and high rates of leukemic transformation. The only curative treatment is stem cell transplantation; therefore, new therapies are needed.[1][1] Recent studies suggest
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a4687e821d8a53ea9f2586fb5d1719 https://doi.org/10.1182/blood-2017-08-801944 Zobrazit plný text záznamu