In-vivo anterior segment OCT imaging provides unique insight into cerulean blue-dot opacities and cataracts in Down syndrome
| Autor: | Patrick Richardson, Kathryn J Saunders, J. Margaret Woodhouse, Aman-Deep Singh Mahil, Valldeflors Vinuela-Navarro, Julie-Anne Little |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Visual acuity genetic structures Cerulean lcsh:Medicine Pixel intensity 0302 clinical medicine Child lcsh:Science Early onset Multidisciplinary Middle Aged Female Down Syndrome de medicine.symptom Tomography Optical Coherence Adult medicine.medical_specialty Down syndrome Adolescent Anterior Chamber Slit Lamp Microscopy Article Cataract Young Adult 03 medical and health sciences Cataracts In vivo Ophthalmology Lens Crystalline medicine Humans Eye manifestations business.industry lcsh:R Down Síndrome de medicine.disease eye diseases Case-Control Studies Potential biomarkers Cataractes 030221 ophthalmology & optometry Lens diseases lcsh:Q Ciències de la visió [Àrees temàtiques de la UPC] sense organs Down Syndrome business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Down syndrome (DS) is frequently associated with cataract, but there remains scant information about DS cataract morphology. Supra-nuclear cataracts in DS have been proposed as indicative of beta-amyloid (Aβ) aggregation and thus potential biomarkers for Alzheimer’s (AD). This study employed anterior segment OCT (AS-OCT) and slit-lamp (SL) photography to image the crystalline lens in DS, compared with adult controls. Lens images were obtained post-dilation. Using MATLAB, AS-OCT images were analysed and lens opacities calculated as pixel intensity and area ratios. SL images were classified using LOCS III. Subjects were n = 28 DS (mean ± SD 24.1 ± 14.3years), and n = 36 controls (54.0 ± 3.4years). For the DS group, AS-OCT imaging revealed the frequent presence of small dot opacities (27 eyes, 50%) in the cortex and nucleus of the lens, covering an area ranging from 0.2–14%. There was no relation with age or visual acuity and these dot opacities (p > 0.5) and they were not present in any control lenses. However, their location and morphology does not coincide with previous reports linking these opacities with Aβ accumulation and AD. Four participants (14%) in the DS group had clinically significant age-related cataracts, but there was no evidence of early onset of age-related cataracts in DS. |
| Databáze: | OpenAIRE |
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