Dosimetric Comparison of Intensity-Modulated Radiotherapy, Volumetric Modulated Arc Therapy and Hybrid Three-Dimensional Conformal Radiotherapy/Intensity-Modulated Radiotherapy Techniques for Right Breast Cancer
Autor: | Hsin-Hon Lin, Yi-Chi Liu, Chia-Chun Lu, Hung-Ming Chang, Lu-Han Lai |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
business.industry
medicine.medical_treatment lcsh:R lcsh:Medicine right breast cancer General Medicine intensity-modulated radiotherapy Volumetric modulated arc therapy Effective dose (radiation) Imaging phantom Article 030218 nuclear medicine & medical imaging Right breast Radiation therapy volumetric modulated arc therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Absorbed dose hybrid 3D-CRT/IMRT Medicine Thermoluminescent dosimeter Radiation protection business Nuclear medicine |
Zdroj: | Journal of Clinical Medicine Volume 9 Issue 12 Journal of Clinical Medicine, Vol 9, Iss 3884, p 3884 (2020) |
ISSN: | 2077-0383 |
DOI: | 10.3390/jcm9123884 |
Popis: | This study aimed to compare different types of right breast cancer radiotherapy planning techniques and to estimate the whole-body effective doses and the critical organ absorbed doses. The three planning techniques are intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT two methods) and hybrid 3D-CRT/IMRT (three-dimensional conformal radiotherapy/intensity-modulated radiotherapy). The VMAT technique includes two methods to deliver a dose: non-continuous partial arc and continuous partial arc. A thermoluminescent dosimeter (TLD) is placed in the RANDO phantom to estimate the organ absorbed dose. Each planning technique applies 50.4 Gy prescription dose and treats critical organs, including the lung and heart. Dose-volume histogram was used to show the planning target volume (V95%), homogeneity index (HI), conformity index (CI), and other optimized indices. The estimation of whole-body effective dose was based on the International Commission on Radiation Protection (ICRP) Publication 60 and 103. The results were as follows: Continuous partial arc and non-continuous partial arc showed the best CI and HI. The heart absorbed doses in the continuous partial arc and hybrid 3D-CRT/IMRT were 0.07 ± 0.01% and 0% (V5% and V10%, respectively). The mean dose of the heart was lowest in hybrid 3D-CRT/IMRT (1.47 Gy ± 0.02). The dose in the left contralateral lung (V5%) was lowest in continuous partial arc (0%). The right ipsilateral lung average dose and V20% are lowest in continuous partial arc. Hybrid 3D-CRT/IMRT has the lowest mean dose to contralateral breast (organs at risk). The whole-body effective doses for ICRP-60 and ICRP-103 were highest in continuous partial arc (2.01 Sv ± 0.23 and 2.89 Sv ± 0.15, respectively). In conclusion, the use of VMAT with continuous arc has a lower risk of radiation pneumonia, while hybrid 3D-CRT/IMRT attain lower secondary malignancy risk and cardiovascular complications. |
Databáze: | OpenAIRE |
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