Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature
| Autor: | Mark Chien-Chin Chen, Mattheos Bobos, Cecilia M Rosales, Nima Mesbah Ardakani, Tim Bracey, Phillip H. McKee, Ahmed Ansari, Shawn Shih, Christopher Savage, Chih-Jung Chen, Carlos A. Cerruto |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pathology medicine.medical_specialty Dermal Neoplasm Dermatology Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Dermis Antigens Neoplasm Predictive Value of Tests Renal cell carcinoma Biomarkers Tumor medicine Humans Endocrine system Aged Aged 80 and over business.industry Papule Nodule (medicine) General Medicine Middle Aged medicine.disease Adenocarcinoma Mucinous Immunohistochemistry Sweat Gland Neoplasms medicine.anatomical_structure Adenocarcinoma Female Mitogen-Activated Protein Kinases medicine.symptom business |
| Zdroj: | The American Journal of Dermatopathology. 41:571-577 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000001370 |
| Popis: | Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are both uncommon low-grade cutaneous adnexal tumors with predilection for the eyelids of elderly women. Their clinical appearance is nonspecific, typically presenting as a slowly growing poorly circumscribed papule, nodule, plaque, or swelling. Histological features of EMPSGC include a lobulated dermal neoplasm with bland cytology and an invasive mucinous component in up to half of the cases. PCMC exhibits tumor nests suspended in abundant pools of mucin with focal strands or nests of tumor cells infiltrating the dermis. Because of their rarity and banal cytological features, both entities pose a risk for misdiagnosis with other benign/malignant cutaneous adnexal neoplasms. Histomorphological features can suggest a diagnosis of EMPSGC or PCMC, but immunohistochemistry is necessary for confirmation. A review of the literature showed variable results of antigens present in EMPSGC, and many of the positive markers only show sparse or focal immunoreactivity of tumor cells. As a result, diffusely positive markers play a crucial role in identification of these tumors, particularly with initial superficial biopsies. We present 9 cases of EMPSGC and 5 cases of PCMC with strong and diffuse immunoreactivity to renal cell carcinoma antigen. This novel finding can be useful in the diagnosis of EMPSGC and PCMC in combination with other known positive markers to differentiate them from other cutaneous neoplasms. In addition, it provides further evidence that EMPSGC could be a precursor lesion to PCMC with both existing on a spectrum. |
| Databáze: | OpenAIRE |
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