Regulation of gonadotropin subunit gene transcription
Autor: | A C Dalkin, D J Haisenleder, Laura L. Burger, John C. Marshall |
---|---|
Rok vydání: | 2004 |
Předmět: |
endocrine system
medicine.medical_specialty Gonad Transcription Genetic medicine.drug_class Biology Gonadotropic cell Gonadotropin-Releasing Hormone Endocrinology Internal medicine medicine Animals Humans Molecular Biology Protein Subunits medicine.anatomical_structure Gene Expression Regulation Hormone receptor Hypothalamus Steroids Gonadotropin Luteinizing hormone hormones hormone substitutes and hormone antagonists Gonadotropins Endocrine gland Hormone |
Zdroj: | Journal of molecular endocrinology. 33(3) |
ISSN: | 0952-5041 |
Popis: | Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the gonadotrope cell and act on the gonad in a sequential and synergistic manner to initiate sexual maturation and maintain cyclic reproductive function. The synthesis and secretion of LH and FSH are regulated mainly by the pulsatile release of the hypothalamic decapeptide hormone gonadotropin-releasing hormone (GnRH). The control of differential LH and FSH synthesis and secretion is complex and involves the interplay between the gonads, hypothalamus and pituitary. In this review, the transcriptional regulation of the gonadotropin subunit genes is discussed in a physiologic setting, and we aimed to examine the mechanisms that drive those changes. |
Databáze: | OpenAIRE |
Externí odkaz: |