Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and/or *04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort
| Autor: | Maxime Dougados, Claire Bombardier, Bernard Combe, Alain Saraux, Carine Salliot |
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| Přispěvatelé: | Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institute for Work and Health (IWH), University of Toronto-St. Michael's Hospital-Institute of Medical Sciences, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 ( UPD7 ), Institute for Work and Health ( IWH ), Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Centre d'Investigation Clinique ( CIC - Brest ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP] |
| Rok vydání: | 2009 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Arthritis Severity of Illness Index Arthritis Rheumatoid 0302 clinical medicine MESH : Peptides Cyclic immune system diseases MESH: Autoantibodies Immunology and Allergy MESH : Female skin and connective tissue diseases HLA-DRB1 MESH: HLA-DRB1 Chains MESH: Arthritis Rheumatoid 0303 health sciences MESH : Estrogen Replacement Therapy MESH: Middle Aged Estrogen Replacement Therapy MESH: Genetic Predisposition to Disease MESH : Adult Middle Aged 3. Good health Menopause MESH: Young Adult Transgender hormone therapy Rheumatoid arthritis Cohort Disease Progression MESH : Severity of Illness Index MESH: Disease Progression Female musculoskeletal diseases Adult medicine.medical_specialty Immunology MESH : Young Adult Peptides Cyclic General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Young Adult MESH : HLA-DR Antigens Rheumatology MESH : Autoantibodies MESH: Severity of Illness Index Internal medicine medicine Humans MESH : Middle Aged Genetic Predisposition to Disease Risk factor MESH: Peptides Cyclic 030304 developmental biology Autoantibodies MESH : HLA-DRB1 Chains 030203 arthritis & rheumatology MESH: Humans [ SDV ] Life Sciences [q-bio] business.industry MESH : Humans MESH: Adult MESH : Disease Progression HLA-DR Antigens MESH: HLA-DR Antigens medicine.disease MESH: Estrogen Replacement Therapy MESH : Arthritis Rheumatoid MESH : Genetic Predisposition to Disease business MESH: Female HLA-DRB1 Chains |
| Zdroj: | Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases, BMJ Publishing Group, 2010, 69 (9), pp.1683-6. ⟨10.1136/ard.2009.111179⟩ Annals of the Rheumatic Diseases, BMJ Publishing Group, 2010, 69 (9), pp.1683-6. 〈10.1136/ard.2009.111179〉 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/ard.2009.111179⟩ |
| Popis: | International audience; OBJECTIVE: To assess the effect of reproductive factors, especially hormone replacement therapy (HRT) and its interaction with HLA-DRB1 *01 and/or *04 alleles on the diagnosis of rheumatoid arthritis (RA) and the presence of anti-cyclic citrullinated peptide (CCP) antibodies in women included in the ESPOIR cohort (early arthritis cohort). METHODS: 568 patients were included in the analyses, which were performed using logistic regression. RESULTS: HRT reduced the risk of RA due to the HLA-DRB1 *01 and/or *04 alleles from OR 1.88 (95% CI 1.32 to 2.68, p |
| Databáze: | OpenAIRE |
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