Impact of Low-Dose Occupational Exposure to Ionizing Radiation on T-Cell Populations and Subpopulations and Humoral Factors Included in the Immune Response
| Autor: | Jana Djounova, Ivanka Rupova, Ilona Gyuleva |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis T cell immunoglobulins NPP personnel Toxicology Ionizing radiation 03 medical and health sciences 0302 clinical medicine Immune system Medicine T-cell populations Chemical Health and Safety biology business.industry lcsh:RM1-950 Low dose Public Health Environmental and Occupational Health Interleukin lcsh:Therapeutics. Pharmacology 030104 developmental biology medicine.anatomical_structure interleukins 030220 oncology & carcinogenesis Immunology biology.protein Original Article Occupational exposure Antibody business low-dose ionizing radiation |
| Zdroj: | Dose-Response Dose-Response, Vol 16 (2018) |
| ISSN: | 1559-3258 |
| Popis: | The aim of the present study is to assess the effects of low-dose occupational exposure on T helper response. One Hundred five employees working in Nuclear Power Plant, Kozloduy, Bulgaria and control group of 32 persons are included in this investigation. Flow cytometry measurements of T-cell populations and subpopulations and natural killer T cells are performed and levels of G, A, and M immunoglobulins and interleukin 2 (IL-2), IL-4, and interferon γ were determined. The data interpreted with regard to cumulative doses, length of service, and age. The results of the present study are not enough to outline a clear impact of occupational radiation exposure on T helper populations. Nevertheless, the observed even slight trends in some lymphocyte’s populations and in cytokines profile give us the reason to assume a possibility of a gradual polarization of T helper 1 to T helper 2 immune response at dose range 100 to 200 mSv. The results of the present study indicate the need to perform a more detailed epidemiological survey including potential confounding and misclassifying factors and possible selection bias that could influence the results. |
| Databáze: | OpenAIRE |
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