| Autor: |
Natalie Elkheir, Chloe Donohue, Daniel Plotkin, Janet T Scott, Louise Sigfrid, John H Amuasi, Muge Cevik, Malcolm G Semple, Kenneth J Baille, Annemarie B Docherty, Sulaiman Lakoh, Thomas M Drake, David J Lowe, Antonia Ho, Katrina Hann, Ibrahim Richard Bangura, Clark D Russell, Nazir I Lone, Madiha Hashmi, Edwin C. Jesudason, Hayley E Hardwick, Gail Carson, Rob Fowler, Lance Turtle, Anna Beltrame, Joanne McPeake, Ewen M Harrison, Carlo Palmieri, Anne Margarita Dyrhol-Riise, Wei Shen Lim, Fernando A. Bozza, Colin Berry, Jan Cato Holter, Daniel Munblit, Jordi Rello, Anders Benjamin Kildal |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Introduction: Very little is known about possible clinical sequelae that may persist after resolution of the acute Coronavirus Disease 2019 (COVID-19). A recent longitudinal cohort from Italy including 143 patients recovered after hospitalisation with COVID-19 reported that 87% had at least one ongoing symptom at 60 day follow-up. Early indications suggest that patients with COVID-19 may need even more psychological support than typical ICU patients. The assessment of risk factors for longer term consequences requires a longitudinal study linked to data on pre-existing conditions and care received during the acute phase of illness. Methods and analysis: This is an international open-access prospective, observational multi-site study. It will enrol patients following a diagnosis of COVID-19. Tier 1 is developed for following up patients day 28 post-discharge, additionally at 3 to 6 months intervals. This module can be used to identify sub-sets of patients experiencing specific symptomatology or syndromes for further follow up. A Tier 2 module will be developed for in-clinic, in-depth follow up. The primary aim is to characterise physical consequences in patients post-COVID-19. Secondary aim includes estimating the frequency of and risk factors for post-COVID-19 medical sequalae, psychosocial consequences and post-COVID-19 mortality. A subset of patients will have sampling to characterize longer term antibody, innate and cell-mediated immune responses to SARS-CoV-2. Ethics and dissemination: This collaborative, open-access study aims to characterize the frequency of and risk factors for long-term consequences and characterise the immune response over time in patients following a diagnosis of COVID-19 and facilitate standardized and longitudinal data collection globally. The outcomes of this study will inform strategies to prevent long term consequences; inform clinical management, direct rehabilitation, and inform public health management to reduce overall morbidity and improve outcomes of COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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