Cardio-Ankle Vascular Index is Independently Associated with Future Cardiovascular Events in Outpatients with Metabolic Disorders
| Autor: | Hidetoshi Kawana, Ichiro Tatsuno, Kei Endo, Yuta Sato, Kohji Shirai, Rena Watanabe, Atsuhito Saiki, Yasuhiro Watanabe, Takanobu Tomaru, Ayako Nagumo, Takumi Kurosu, Noriko Ban, Masahiro Ohira, Takashi Yamaguchi, Haruki Imamura, Daiji Nagayama |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure 030204 cardiovascular system & hematology Angina Pectoris Angina 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Metabolic Diseases Risk Factors Internal medicine Diabetes mellitus Atrial Fibrillation Outpatients Diabetes Mellitus Internal Medicine medicine Humans Ankle Brachial Index Prospective Studies 030212 general & internal medicine Myocardial infarction Aged Dyslipidemias Glycated Hemoglobin business.industry Body Weight Biochemistry (medical) Hazard ratio Atrial fibrillation Middle Aged medicine.disease Quartile Cardiovascular Diseases Hypertension Arterial stiffness Cardiology Female Ankle Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 23:596-605 |
| ISSN: | 1880-3873 1340-3478 |
| DOI: | 10.5551/jat.31385 |
| Popis: | AIM We investigated whether cardio-ankle vascular index (CAVI), an arterial stiffness marker, independently predicts future cardiovascular events in subjects with metabolic disorders. METHODS 1562 outpatients underwent CAVI between April 2004 and March 2006 at Toho University, Sakura Medical Center in Chiba, Japan. Patients who already had cardiovascular events at baseline, patients with low ankle brachial index (＜0.9), and patients with atrial fibrillation were excluded. After exclusion, 1080 subjects with metabolic disorders including diabetes mellitus, hypertension and dyslipidemia were screened and followed prospectively. RESULTS Eventually, 1003 subjects (92.9% of 1,080 subjects) followed until March 2012 (follow-up duration 6.7±1.6 years) were analyzed. During the observation period, 90 subjects had new-onset myocardial infarction or angina pectoris confirmed by angiography. All subjects were stratified into quartiles by baseline CAVI (Q1: CAVI ≤8.27, Q2: CAVI 8.28-9.19, Q3: CAVI 9.20-10.08, Q4: CAVI ≥10.09). Age, male ratio and future cardiovascular events increased as CAVI quartile became higher. In Cox proportional hazards regression analysis, the factors independently associated with higher risk of future cardiovascular events were every 1.0 increment of CAVI [hazard ratio (HR) 1.126, p= 0.039], male gender (HR 2.276, p=0.001), smoking (HR 1.846, p=0.007), diabetes mellitus (HR 1.702,p=0.020), and hypertension (HR 1.682, p=0.023). CONCLUSION In individuals with metabolic disorders, CAVI was a predictor of future cardiovascular events, independent of traditional coronary risk factors. CAVI is a potentially valuable tool to identify persons likely to benefit from more intensive therapeutic approaches. |
| Databáze: | OpenAIRE |
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