The progestin etonogestrel enhances the respiratory response to metabolic acidosis in newborn rats. Evidence for a mechanism involving supramedullary structures
| Autor: | Fanny Joubert, Christian Straus, Diane Osinski, Thomas Similowski, Laurence Bodineau, Camille Loiseau |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Central nervous system Rats Sprague-Dawley Desogestrel Mesencephalon Internal medicine Parafacial medicine Animals Respiratory system Diencephalon Etonogestrel Medulla Oblongata business.industry General Neuroscience Metabolic acidosis Hydrogen-Ion Concentration Respiratory Center medicine.disease Hypoventilation Endocrinology medicine.anatomical_structure Animals Newborn Medulla oblongata medicine.symptom Progestins business Acidosis medicine.drug |
| Zdroj: | Neuroscience letters. 567 |
| ISSN: | 1872-7972 |
| Popis: | Central congenital hypoventilation syndrome is a neuro-respiratory disease characterized by the dysfunction of the CO2/H(+) chemosensitive neurons of the retrotrapezoid nucleus/parafacial respiratory group. A recovery of CO2/H(+) chemosensitivity has been observed in some central congenital hypoventilation syndrome patients coincidental with contraceptive treatment by a potent progestin, desogestrel (Straus et al., 2010). The mechanisms of this progestin effect remain unknown, although structures of medulla oblongata, midbrain or diencephalon are known to be targets for progesterone. In the present study, on ex vivo preparations of central nervous system of newborn rats, we show that acute exposure to etonogestrel (active metabolite of desogestrel) enhanced the increased respiratory frequency induced by metabolic acidosis via a mechanism involving supramedullary structures located in pontine, mesencephalic or diencephalic regions. |
| Databáze: | OpenAIRE |
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