T cell costimulation by chemokine receptors
| Autor: | Barbara Molon, Santos Mañes, Carlos Martínez-A, Antonio Lanzavecchia, Monica Bettella, Concepción Gómez-Moutón, Antonella Viola, Giorgia Gri |
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| Přispěvatelé: | Molon B., Gri G., Bettella M., Gomez-Mouton C., Lanzavecchia A., Martinez-A C., Manes S., Viola A. |
| Rok vydání: | 2004 |
| Předmět: |
Cells
T-Lymphocytes Immunology Antigen-Presenting Cells C-C chemokine receptor type 6 Biology Lymphocyte Activation CCL5 Chemokine receptor Cell Adhesion Cells Cultured GTP-Binding Protein alpha Subunits Gq-G11 Humans Protein Binding Receptors Chemokine Receptors Immunology and Allergy CXCL10 CXC chemokine receptors Antigen-Presenting Cell Gq-G11 Cultured Molecular biology GTP-Binding Protein alpha Subunits Cell biology Chemokine XCL2 CC chemokine receptors CCL21 Human |
| Zdroj: | Nature immunology. 6(5) |
| ISSN: | 1529-2908 |
| Popis: | Signals mediated by chemokine receptors may compete with T cell receptor stop signals and determine the duration of T cell-antigen-presenting cell interactions. Here we show that during T cell stimulation by antigen-presenting cells, T cell chemokine receptors coupled to G(q) and/or G(11) protein were recruited to the immunological synapse by a G(i)-independent mechanism. When chemokine receptors were sequestered at the immunological synapse, T cells became insensitive to chemotactic gradients, formed more stable conjugates and finally responded with enhanced proliferation and cytokine production. We suggest that chemokine receptor trapping at the immunological synapse enhances T cell activation by improving T cell-antigen-presenting cell attraction and impeding the 'distraction' of successfully engaged T cells by other chemokine sources. |
| Databáze: | OpenAIRE |
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