Brucellosis in pregnancy: results of multicenter ID-IRI study

Autor: Seval Bilgic-Atli, Hakan Erdem, Ayşe Erbay, Nicholas J. Beeching, Ergin Ayaslioglu, Recep Tekin, Mile Bosilkovski, S. Sahin, Mehmet Ulug, Tuna Demirdal, Serap Ural, Alper Şener, Tansu Yamazhan, Asuman Inan, Emsal Aydin, Selma Tosun, Asli Haykir-Solay, Serda Gulsun, Selçuk Kaya, Nazif Elaldi, Pınar Ergen, Abdullah Umut Pekok, Elif Sahin-Horasan, Murat Muhcu, Mustafa Kasim Karahocagil, Mahmut Sunnetcioglu, Ayten Kadanali, Yakup Cag, Ali Avci, Şafak Kaya
Přispěvatelé: Kırıkkale Üniversitesi, [Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, Hakan] Gulhane Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, Serda -- Kaya, Safak -- Bilgic-Atli, Seval] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karahocagil, Mustafa K.] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Pekok, Abdullah U.] Pendik Med Pk Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ulug, Mehmet] Private Umut Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Bosilkovski, Mile] Skopje Med Fac, Dept Infect Dis & Febrile Condit, Skopje, Macedonia -- [Haykir-Solay, Asli] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Demirdal, Tuna -- Ural, Serap] Katip Celebi Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Aydin, Emsal] Kafkas Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kars, Turkey -- [Yamazhan, Tansu] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Muhcu, Murat] GATA Haydarpasa Training Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Ayaslioglu, Ergin] Kirikkale Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kirikkale, Turkey -- [Erbay, Ayse] Bozok Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Yozgat, Turkey -- [Ergen, Pinar] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kadanali, Ayten] Umraniye Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Sahin, Suzan] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Avci, Ali] Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Urol, Izmir, Turkey -- [Cag, Yakup] Turkish Hlth Sci Univ, Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Beeching, Nicholas J.] Univ Liverpool Liverpool Sch Trop Med, Clin Sci, Liverpool, Merseyside, England
Rok vydání: 2019
Předmět:
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases. 38:1261-1268
ISSN: 1435-4373
0934-9723
3098-9418
Popis: WOS: 000471726700008
PubMed ID: 30989418
Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
Databáze: OpenAIRE
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