Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31–34
| Autor: | Pablo Davanzo, Daniel Ortiz, Carlos Palacio, Constanza Duque, Matthew Levinson, Carmen Araya Ortiz, Guadalupe Polanco, Carlos López, Carol A. Mathews, Andrés Ruiz-Linares, Gabriel J. Restrepo, Magui Ramirez, Barbara Kremeyer, Julio Bejarano, Julio Molina, Damini Jawaheer, Gabriel Bedoya, Nelson B. Freimer, Victor I. Reus, Jorge Vega, María Victoria Parra, Xinia Araya, Jenny García, L. Carvajal, Ileana Aldana, Anna J. Jasinska, Chiara Sabatti, Gabriel Macaya, Eduardo Fournier, Jorge Ospina, Ibi Herzberg |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Costa Rica
Male Bipolar Disorder Population Colombia Biology Statistics Nonparametric Gene mapping Genetic linkage Genetics medicine Humans Genetic Predisposition to Disease Bipolar disorder education Molecular Biology Genetics (clinical) Linkage (software) education.field_of_study Genome Human Haplotype General Medicine medicine.disease Founder Effect Pedigree Chromosomes Human Pair 5 Microsatellite Female Lod Score Microsatellite Repeats Founder effect |
| Zdroj: | Human Molecular Genetics. 15:3146-3153 |
| ISSN: | 1460-2083 0964-6906 |
| Popis: | We performed a whole genome microsatellite marker scan in six multiplex families with bipolar (BP) mood disorder ascertained in Antioquia, a historically isolated population from North West Colombia. These families were characterized clinically using the approach employed in independent ongoing studies of BP in the closely related population of the Central Valley of Costa Rica. The most consistent linkage results from parametric and non-parametric analyses of the Colombian scan involved markers on 5q31-33, a region implicated by the previous studies of BP in Costa Rica. Because of these concordant results, a follow-up study with additional markers was undertaken in an expanded set of Colombian and Costa Rican families; this provided a genome-wide significant evidence of linkage of BPI to a candidate region of approximately 10 cM in 5q31-33 (maximum non-parametric linkage score=4.395, P0.00004). Interestingly, this region has been implicated in several previous genetic studies of schizophrenia and psychosis, including disease association with variants of the enthoprotin and gamma-aminobutyric acid receptor genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|