The Association between the Alcohol Biomarker Phosphatidylethanol (PEth) and Self-Reported Alcohol Consumption among Russian and Norwegian Medical Patients
| Autor: | Alexey J. Kolgashkin, Benedicte Jørgenrud, Elena Tetenova, Anners Lerdal, S.N. Perekhodov, Vigdis Vindenes, Saranda Kabashi, Aleksei V. Nadezhdin, Gudmund Norby, Evgeny Bryun, A. E. Petukhov, Elena N. Davydova, Danil Gamboa, Stig Tore Bogstrand, Evgenya Koshkina |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Alcohol Drinking Hospitalized patients Alcohol Harmful drinking Glycerophospholipids Norwegian Article Russia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Predictive Value of Tests Environmental health Humans Medicine AcademicSubjects/MED00860 030212 general & internal medicine Alcohol Use Disorders Identification Test Norway business.industry General Medicine Hospitals language.human_language Cross-Sectional Studies ROC Curve chemistry language Biomarker (medicine) Female Phosphatidylethanol Self Report business Alcohol consumption Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Alcohol and Alcoholism (Oxford, Oxfordshire) |
| ISSN: | 0735-0414 |
| Popis: | Aims Valid measures to identify harmful alcohol use are important. Alcohol Use Disorders Identification Test (AUDIT) is a validated questionnaire used to self-report harmful drinking in several cultures and settings. Phosphatidylethanol 16:0/18:1 (PEth) is a direct alcohol biomarker measuring alcohol consumption levels. The aim of this study was to investigate how PEth levels correlate with AUDIT-QF and weekly grams of alcohol consumed among patients in two urban hospitals. In addition, we wanted to investigate the predictive value of PEth in identifying harmful alcohol use as defined by AUDIT-QF and weekly grams of alcohol cutoffs. Methods A cross-sectional study comprising acute medically ill patients with measurable PEth levels (≥0.030 μM) admitted to two urban hospitals in Oslo, Norway (N = 931) and Moscow, Russia (N = 953) was conducted using PEth concentrations in whole blood, sociodemographic data and AUDIT-QF questionnaires. Results PEth levels from patients with measurable PEth were found to be positively correlated with AUDIT-QF scores, with PEth cutpoints of 0.128 μM (Oslo) and 0.270 μM (Moscow) providing optimal discrimination for harmful alcohol use defined by AUDIT-QF (the difference between cities probably reflecting different national drinking patterns in QF). When converting AUDIT-QF into weekly grams of alcohol consumed, the predictive value of PEth improved, with optimal PEth cutpoints of 0.327 (Oslo) and 0.396 (Moscow) μM discriminating between harmful and non-harmful alcohol use as defined in grams (≥350 grams/week). Conclusions By using PEth levels and converting AUDIT-QF into weekly grams of alcohol it was possible to get an improved rapid and sensitive determination of harmful alcohol use among hospitalized patients. Short Summary: AUDIT-QF among acute medically ill patients was found to be positively correlated with the alcohol biomarker PEth, with improved predictive value of PEth when converting AUDIT-QF to weekly grams of alcohol. PEth may be used to discriminate harmful alcohol use in clinical settings. |
| Databáze: | OpenAIRE |
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