Pyridoxine-Related Metabolite Concentrations in Normal and Down Syndrome Amniotic Fluid
| Autor: | James D. Shoemaker, Anna Jane Y. Eliseo, Paddy Jim Baggot, Jeremy A. Kalamarides, Nathaniel G. DeNicola |
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| Rok vydání: | 2008 |
| Předmět: |
Paper
Xanthurenates Embryology medicine.medical_specialty Down syndrome Amniotic fluid Pyridoxic Acid Metabolite chemistry.chemical_compound Pregnancy Prenatal Diagnosis Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Kynurenine Retrospective Studies business.industry Oxalic Acid Pyridoxine Obstetrics and Gynecology General Medicine Metabolism Amniotic Fluid medicine.disease Endocrinology chemistry Case-Control Studies Pediatrics Perinatology and Child Health Female Down Syndrome business Trisomy Biomarkers medicine.drug |
| Zdroj: | Fetal Diagnosis and Therapy. 23:254-257 |
| ISSN: | 1421-9964 1015-3837 |
| DOI: | 10.1159/000123610 |
| Popis: | Introduction: Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B6); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome. Materials and Methods: Archived specimens of amniotic fluid were obtained from chromosomally normal and from fetuses with Down syndrome. Gas chromatography/mass spectrometry quantitized B-related metabolites, including oxalate, xanthurenate, kynurenine and 4-pyridoxic acid. Results: Oxalate, a marker of pyridoxine deficiency, was elevated in the amniotic fluid of fetuses with Down syndrome. This result was statistically significant. The other marker results were not statistically significant. Conclusion: A marker of pyridoxine deficiency, oxalate is elevated in the amniotic fluid of fetuses with Down syndrome. These results in amniotic fluid are consistent with previous studies done in the urine of young children. |
| Databáze: | OpenAIRE |
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