Maturation of the cardiac autonomic regulation system, as function of gestational age in a cohort of low risk preterm infants born between 28 and 32 weeks of gestation
| Autor: | Zuk Luba, Mendlovic Joseph, Israeli-Mendlovic Hadas, Katz-Leurer Michal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Sympathetic nervous system Sympathetic Nervous System Respiratory rate Pregnancy Trimester Third Physiology Gestational Age Electrocardiography 03 medical and health sciences 0302 clinical medicine Fetal Organ Maturity Heart Rate Pregnancy Heart Rate Determination 030225 pediatrics Humans Medicine Heart rate variability Vagal tone business.industry Infant Newborn Postmenstrual Age Obstetrics and Gynecology Gestational age Heart Vagus Nerve medicine.anatomical_structure Pediatrics Perinatology and Child Health Cohort Gestation Female business Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Journal of Perinatal Medicine. 49:624-629 |
| ISSN: | 1619-3997 0300-5577 |
| DOI: | 10.1515/jpm-2020-0482 |
| Popis: | Objectives The maturation of the sympathetic nervous system (SNS) occurs steadily throughout gestation while the myelinated vagus has accelerated maturation periods, between 25 and 32 weeks of gestation and a further increase around 37–38 weeks of gestation. The aim was to quantify the cardiac autonomic regulation maturation, as a function of gestational age (GA) in a cohort of low risk preterm infants born between 28 and 32 weeks of gestation by assessing heart rate variability (HRV) at week 32, and at week 35 postmenstrual age (PMA). Methods Forty preterm infants were recruited, 24 h recordings of breathing rate and RR intervals were obtained at week 32 and week 35 PMA. Results A significant difference was noted between preterm infants born before 32 weeks GA and preterm infants born at week 32; the latter present higher HRV values throughout the follow-up period. No significant change over time was noted for the parasympathetic HRV measures while a significant increase was found in the sympathetic system. Moreover, a significant interaction effect of time and system was found, the increase in values of the sympathetic system over time was significantly larger than the change noted in the vagal HRV measures. Conclusions Given the beneficial influence of vagal tone on health and developmental outcomes in preterm infants, the findings of the current study highlight the need for further studies on the impact of specifics gestational age on vagal development and later assessing interventions associate with its continue development and maturation at these specific periods. |
| Databáze: | OpenAIRE |
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