A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine

Autor:	Fiona M. Thompson, Adrian V. S. Hill, Sarah C. Gilbert, Eric Prieur, Ian D. Poulton, Simon Correa, Tamara Berthoud, Jackie Williams, Claire Hutchings, Sumi Biswas, Trudie Lang, Laura Andrews, Robert E. Sinden, David W. Porter, Stephen Todryk, Rosalind Rowland
Rok vydání:	2011
Předmět:	viruses Protozoan Proteins Antibodies Protozoan 0302 clinical medicine Heterologous prime-boost Malaria Falciparum 0303 health sciences Malaria vaccine ELISPOT Immunogenicity Vaccination Middle Aged 3. Good health Treatment Outcome Infectious Diseases Vaccines Subunit Molecular Medicine Adult Adolescent 030231 tropical medicine Plasmodium falciparum Immunization Secondary Antigens Protozoan Biology complex mixtures Article 03 medical and health sciences Interferon-gamma Young Adult Antigen Immunology and Microbiology(all) parasitic diseases Malaria Vaccines medicine Humans 030304 developmental biology Polyproteins General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health biology.organism_classification Vaccine efficacy medicine.disease Virology veterinary(all) Malaria Immunology Vaccine
Zdroj:	Vaccine
ISSN:	0264-410X
DOI:	10.1016/j.vaccine.2011.03.083
Popis:	We examined the safety, immunogenicity and efficacy of a prime-boost vaccination regime involving two poxvirus malaria subunit vaccines, FP9-PP and MVA-PP, expressing the same polyprotein consisting of six pre-erythrocytic antigens from Plasmodium falciparum. Following safety assessment of single doses, 15 volunteers received a heterologous prime-boost vaccination regime and underwent malaria sporozoite challenge. The vaccines were safe but interferon-γ ELISPOT responses were low compared to other poxvirus vectors, despite targeting multiple antigens. There was no vaccine efficacy as measured by delay in time to parasitaemia. A number of possible explanations are discussed, including the very large insert size of the polyprotein transgene. © 2011 Elsevier Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209339e6f42eb5bea19ac46445d16ee2 Zobrazit plný text záznamu Full Text from ScienceDirect