Endothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus
| Autor: | Valeria C. Sandrim, Hugo Roberto Kurtz Lisboa, Glaucia Sarturi Tres, Jose E. Tanus-Santos, Roger W.C. de Syllos |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Nitric Oxide Synthase Type III endocrine system diseases Single-nucleotide polymorphism Type 2 diabetes Polymerase Chain Reaction Risk Factors Enos Internal medicine Diabetes mellitus Genotype medicine Humans Genetic Predisposition to Disease Alleles Polymorphism Genetic biology Haplotype nutritional and metabolic diseases DNA Middle Aged Prognosis medicine.disease biology.organism_classification Nitric oxide synthase Variable number tandem repeat Endocrinology Diabetes Mellitus Type 2 Haplotypes Hypertension biology.protein Female Cardiology and Cardiovascular Medicine |
| Zdroj: | Atherosclerosis. 189:241-246 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2005.12.011 |
| Popis: | Type 2 diabetes mellitus (T2DM) and hypertension (HT) commonly coexist. While endothelial nitric oxide synthase (eNOS) haplotypes have been associated with HT, it is unknown whether eNOS genotypes/haplotypes are associated with altered susceptibility to HT in patients with T2DM. We studied the distribution of three eNOS genetic polymorphisms: a single nucleotide polymorphism in the promoter region (T(-786)C), in exon 7 (Glu298Asp), and a variable number of tandem repeats in intron 4(b/a). Genotypes were determined for 102 healthy controls, 119 patients with HT, 66 patients with T2DM, and 113 patients with T2DM+HT. In addition, we also compared the distribution of eNOS haplotypes in the four groups of subjects. No differences were found in genotype and allele distribution among the four groups. Conversely, the haplotypes "C Glu b" and "C Asp b" were, respectively, more and less common in healthy controls than in HT or in T2DM+HT groups (24% versus 6% and 5%, respectively; both P0.00625; and 8% versus 18% and 18%, respectively; both P0.00625). Moreover, DM patients presented an overall distribution of eNOS haplotypes that was not different from healthy controls (P0.05). Additionally, the haplotypes "C Glu b" and "C Asp b" were, respectively, more and less common in T2DM group than in T2DM+HT group (19% versus 5%; and 7% versus 18%, respectively; both P0.00625). Our findings suggest a protective effect for eNOS haplotype "C Glu b" against the development of hypertension, and that haplotype "C Asp b" increases the susceptibility to hypertension in patients without or with T2DM. |
| Databáze: | OpenAIRE |
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