Genetic manipulation of insulin signaling, action and secretion in mice

Autor: Anne Baudry, Malene Jackerott, Rajiv L. Joshi, Loïc Leroux
Přispěvatelé: Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2002
Předmět:
medicine.medical_specialty
Potassium Channels
Monosaccharide Transport Proteins
[SDV]Life Sciences [q-bio]
medicine.medical_treatment
Transgene
Reviews
Muscle Proteins
Type 2 diabetes
Bioinformatics
Biochemistry
Diabetes Mellitus
Experimental
Animals
Genetically Modified
Islets of Langerhans
Mice
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Internal medicine
Insulin Secretion
Genetics
medicine
Animals
Insulin
Glucose homeostasis
Molecular Biology
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
Glucose Transporter Type 4
biology
Phosphoproteins
medicine.disease
3. Good health
Insulin receptor
Glucose
Endocrinology
Diabetes Mellitus
Type 2
Genetically Engineered Mouse
Knockout mouse
biology.protein
030217 neurology & neurosurgery
Signal Transduction
Zdroj: EMBO Reports
EMBO Reports, EMBO Press, 2002, 3 (4), pp.323-328. ⟨10.1093/embo-reports/kvf078⟩
ISSN: 1469-3178
1469-221X
Popis: Non-insulin-dependent diabetes mellitus (NIDDM) is a complex heterogeneous polygenic disease characterized mainly by insulin resistance and pancreatic beta-cell dysfunction. In recent years, several genetically engineered mouse models have been developed for the study of the pathophysiological consequences of defined alterations in a single gene or in a set of candidate diabetogenes. These represent new tools that are providing invaluable insights into NIDDM pathogenesis. In this review, we highlight the lessons emerging from the study of some of the transgenic or knockout mice in which the expression of key actors in insulin signaling, action or secretion has been manipulated. In addition to contributing to our knowledge of the specific roles of individual genes in the control of glucose homeostasis, these studies have made it possible to address several crucial issues in NIDDM that have remained controversial or unanswered for a number of years.
Databáze: OpenAIRE
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