TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses
| Autor: | Hiromi Yamaguchi, Kazuhiko Kanou, Mariko Esumi, Atsushi Kato, Masako Abe, Katsumi Maenaka, Hideo Fukuhara, Maino Tahara, Kazuya Shirato, Makoto Takeda, Hirokazu Kimura, Kouji Sakai, Shutoku Matsuyama, Yasushi Ami, Miyuki Kawase, Katsumi Mizuta, Masahiro Noda |
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| Rok vydání: | 2013 |
| Předmět: |
viruses
medicine.medical_treatment Immunology Viral Plaque Assay Biology urologic and male genital diseases Virus Replication TMPRSS2 Microbiology Cell Line Serine Virology medicine Animals Humans Paramyxovirinae Protease Serine Endopeptidases virus diseases Lipid bilayer fusion Epithelial Cells Viral Load respiratory system biology.organism_classification Sendai virus Virus-Cell Interactions Human Parainfluenza Virus Viral replication Insect Science Host-Pathogen Interactions |
| Zdroj: | Journal of Virology |
| ISSN: | 0022-538X |
| DOI: | 10.1128/jvi.01490-13 |
| Popis: | Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia. |
| Databáze: | OpenAIRE |
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