Radioprotective effects of the immunostimulating lauroylpeptide LtriP (RP 56142)
| Autor: | M. Sedqi, A. Naussac, D. Migliore-Samour, C. Ferradini, J. M. Caillaud, A. Bousseau, Pierre Jollès |
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| Rok vydání: | 1993 |
| Předmět: |
Cell Survival
Ratón Mrna expression medicine.medical_treatment Gene Expression Mice Inbred Strains Radiation-Protective Agents Pharmacology Biology Lymphocyte Activation Leukocyte Count Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Adjuvants Immunologic medicine Animals Secretion Irradiation Molecular Biology Tumor Necrosis Factor-alpha Interleukins Macrophage Colony-Stimulating Factor Pimelic Acids Lipopeptide Cell Biology Survival Analysis Hematopoiesis Cytokine Biochemistry chemistry Cytokines Molecular Medicine Female Tumor necrosis factor alpha Oligopeptides Lipoprotein |
| Zdroj: | Experientia. 49:160-166 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01989422 |
| Popis: | The lipopeptide lauroyl-L-Ala-gamma-D-Glu-L,L-A2pm (LtriP) increased the resistance of mice to the lethal effect of gamma-ray irradiation. The radioprotective effect was dependent on the doses of LtriP and of radiation. Maximum survival was observed when the lipopeptide was injected on two successive days before irradiation. This activity seems to be related to immunostimulating functions, since the non-immunostimulating analog lauroyl-L-Ala-gamma-D-Glu-D,D-A2pm-Gly, containing D,D-diaminopimelic acid, was not radioprotective. The protective activity might result from an induction of cytokines, such as IL-1, TNF and M-CSF, since LtriP induced the mRNA expression and the secretion of these immunomodulators. |
| Databáze: | OpenAIRE |
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