Can reduced leftward asymmetry of white matter integrity be a marker of transition to psychosis in at-risk mental state?
| Autor: | Tomoyuki Funatogawa, Naoyuki Katagiri, Naohisa Tsujino, Masafumi Mizuno, Junichi Saito, Takahiro Nemoto, Hiromi Tagata, Taiju Yamaguchi, Masaaki Hori |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Psychosis
medicine.medical_specialty Uncinate fasciculus Audiology White matter 03 medical and health sciences 0302 clinical medicine Fractional anisotropy Medicine Brain asymmetry Humans General Psychology business.industry Brain At risk mental state General Medicine medicine.disease White Matter 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Diffusion Tensor Imaging Psychotic Disorders Schizophrenia Laterality Anisotropy business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Asian journal of psychiatry. 54 |
| ISSN: | 1876-2026 |
| Popis: | As a biomarker for the degree of psychosis development, the lateral asymmetry of white matter (WM) integrity in each area of the cerebrum has been investigated; as a result, a reduced leftward asymmetry of WM integrity has been reported in patients with schizophrenia. Although individuals with an at-risk mental state for psychosis (ARMS) who subsequently develop psychosis are believed to have poorer social functioning, only a few studies have actually examined the associations between WM abnormalities and social functioning. The aim of the present study was to clarify the possibly predictive association between a reduced asymmetry of WM integrity and impairments in social functioning in patients with ARMS. Thirty ARMS subjects underwent MRI scanning and were assessed using the Social Functioning Scale (SFS). We examined the fractional anisotropy (FA) values in the cingulum bundle (CB) and the uncinate fasciculus (UF) using a tract-specific analysis. Lateral asymmetry was assessed using the laterality index (LI). The LI of the FA value was positive (leftward) in the CB and negative (rightward) in the UF. Although the LI was not correlated with the Scale of Prodromal Symptoms (SOPS) score, the LI in the CB was positively correlated with the SFS score. In ARMS patients, the degree of reduced leftward asymmetry in the CB might affect deteriorations in social functioning and may be useful as a biomarker for predicting future outcomes at an early stage of psychosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect