Metabolic Coronary-Flow Regulation and Exogenous Nitric Oxide in Human Coronary Artery Disease: Assessment by Intravenous Administration of Nitroglycerin
| Autor: | Jasper E. Kal, H. B. Van Wezel, Isabelle Vergroesen, M. Porsius, J. A. E. Spaan |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2000 |
| Předmět: |
Male
Vasodilator Agents Coronary Disease Vasodilation Nitric Oxide Nitric oxide Coronary artery disease Nitroglycerin chemistry.chemical_compound Oxygen Consumption Heart Rate Coronary Circulation medicine Humans Nitric Oxide Donors Sinus rhythm Lactic Acid Cardiac Output Coronary sinus Aged Pharmacology Vascular disease business.industry Myocardium Cardiac Pacing Artificial Blood flow Middle Aged medicine.disease Thrombosis eye diseases chemistry Anesthesia Injections Intravenous sense organs Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cardiovascular pharmacology, 35(1), 7-15. Lippincott Williams and Wilkins |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200001000-00002 |
| Popis: | We sought to evaluate the effect of intravenous administration of the nitric oxide--donor substance nitroglycerin (NTG) on metabolic coronary-flow regulation in patients with coronary artery disease (CAD). In 12 patients with stable CAD, we measured coronary sinus blood flow and myocardial oxygen supply and consumption (MVO2) at sinus rhythm and during atrial pacing (30 beats/min above sinus rate), both at control and during infusion of NTG, 1 microg/kg/min, and NTG, 2 microg/kg/min. To study metabolic coronary vasodilation, changes in myocardial oxygen supply were related to pacing-induced changes in MVO2, by using standard regression analysis. The myocardial oxygen supply/consumption ratio (i.e., the slope of the regression line at control, characterizing physiological metabolic coronary flow regulation) was compared with the ratios obtained during infusion of NTG. Compared with control measurements, NTG, 1 microg/kg/min, and NTG, 2 microg/kg/min, attenuated pacing-induced increases in MVO2 by 29 and 60%, respectively, whereas coronary blood flow during pacing remained unchanged. At control, normal metabolic coronary-flow regulation resulted in a myocardial oxygen supply/demand ratio of 1.39 (95% CI, 1.29-1.49). This ratio did not change during NTG, 1 microg/kg/min: 1.44 (95% CI, 1.33-1.56). However, during NTG, 2 microg/kg/min, this ratio significantly increased to 1.84 (95% CI, 1.63-2.05; p |
| Databáze: | OpenAIRE |
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