| Popis: |
Department of Chemistry, Karnatak University, Dharwar-580 003 Manuscript received 9 June 1976, revised 8 November 1976, accepted 10 November 1976 3-Nitro-4-chloro-\(\alpha\)-aminoacetophenone hydrochloride III on treatment with 2,2'-dichloroacetyl chloride yields the corresponding \(\alpha\)-dichloroacetamido derivative (IV). Hydroxymethylation of IV followed by Meerwein-Poundorf-Verley reduction yields the desired chloramphenicol analogue, dl-threo-2-dichloroacetantido-1-(4-chloro-3-nitropheny-1-)-propane-1,3-diol(VI). |
