10 most important contemporary challenges in the management of SLE
| Autor: | Pauline Soulas-Sprauel, Marianne Rivière, Rose-Marie Javier, Anne-Sophie Korganow, Aurélien Guffroy, Laurent Arnaud, Renaud Felten, Christelle Sordet, Florence Scher, P.E. Gavand, Thierry Martin, Vincent Poindron, Flora Sagez |
|---|---|
| Přispěvatelé: | Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject Immunology Physical activity Complex disease Fertility Review Disease Sciences du Vivant [q-bio]/Santé publique et épidémiologie Disease activity 03 medical and health sciences 0302 clinical medicine systemic lupus erythematosus medicine Intensive care medicine 030304 developmental biology media_common 030203 arthritis & rheumatology 0303 health sciences Pregnancy glucocorticoids business.industry Treat to target General Medicine medicine.disease 3. Good health Disease remission [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business disease activity damage |
| Zdroj: | Lupus science & medicine Lupus science & medicine, BMJ, 2019, 6 (1), ⟨10.1136/lupus-2018-000303⟩ Lupus Science & Medicine |
| ISSN: | 2053-8790 |
| DOI: | 10.1136/lupus-2018-000303⟩ |
| Popis: | From a 1-year survival of less than 50% before the discovery of glucocorticoids to over 90% at 10 years in most dedicated centres, the spectrum of SLE has profoundly evolved. Despite this improvement, several major challenges currently remain. The aim of this review is to analyse what are, according to us, the 10 most important contemporary challenges in the management of SLE. Among those are the need to treat to target to favour disease remission (or low disease activity), limit the use of glucocorticoids, derive more comprehensive tools for the evaluation of disease activity, develop more effective drugs (yielding successful trials), dissect the heterogeneity of the disease both at the molecular and genetic levels, identify relevant biomarkers for individualised treatment, manage fertility and pregnancy, tackle comorbidities such as cardiovascular risk, the prevention of infections and osteoporosis, improve the network of care (from the patients' perspective), and favour a holistic approach (integrating fatigue, adherence to treatment, physical activity). Altogether, these 10 contemporary challenges in SLE may be considered as a roadmap for those involved in the daily care of patients with SLE, as well as for researchers who may wish to contribute to an improved management of this rare and complex disease. journal article review 2019 2019 01 10 imported |
| Databáze: | OpenAIRE |
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