Disruption of male sexual behavior in rats by tetrahydrofurandiols (THF-diols)
| Autor: | Andrea Reyna, Jan R. Crowley, Mary Alejandro, Barry M. Markaverich, Shaila K. Mani |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Linoleic acid Clinical Biochemistry Phytoestrogens Biology Hydroxylation Zea mays Biochemistry Steroid Rats Sprague-Dawley Sexual Behavior Animal chemistry.chemical_compound Endocrinology Internal medicine Male rats medicine Animals Furans Molecular Biology Pharmacology Organic Chemistry Housing Animal Rats Linoleic Acids Sexual behavior chemistry |
| Zdroj: | Steroids. 70:750-754 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/j.steroids.2005.04.004 |
| Popis: | The mitogenic agent that disrupts male and female sexual behavior has been isolated from corncob bedding. The disrupting activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl groups (THF-diols) that include 9, (12)-oxy-10, 13-dihydroxtstearic acid and 10, (13)-oxy-9, 12-dihydroxystearic acid. We examined the effects of exposure of male rats to THF-diols in drinking water on several parameters of male sexual behavior. THF-diols disrupt sexual behavior in male rats by reducing mounting and intromission frequencies. The mount, intromission and ejaculatory latencies are enhanced while the ejaculatory responses are diminished. These findings suggest that the THF-diols modulate hypothalamo-pituitary axis to regulate steroid hormone-dependent male sexual behavior. |
| Databáze: | OpenAIRE |
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