Developing a core outcome set for fistulising perianal Crohn’s disease
Autor: | Sahnan, K, Tozer, PJ, Adegbola, SO, Lee, MJ, Heywood, N, McNair, AGK, Hind, D, Yassin, N, Lobo, AJ, Brown, SR, Sebastian, S, Phillips, RKS, Lung, PFC, Faiz, OD, Crook, K, Blackwell, S, Verjee, A, Hart, AL, Fearnhead, NS, John, A, Austin, A, Simon, A, Aidan, A, James, A, Katherine, A, Sathish, B, Ian, B, Gauraang, B, Stuart, B, Dominic, B, Matthew, B, David, B, Jeffrey, B, Christopher, C, Rachel, C, Peter, C, Thomas, C, Tamzin, C, Robert, D, Walter, D, Irene, D, Jayne, E, Jonathan, E, Martyn, E, Simon, F, Beverley, F, Catherine, F, James, G, Catherine, G, Ben, G, Arun, G, Sanjay, G, Richard, G, Alex, H, Diane, H, Nigel, H, Steve, H, Laura, H, Marcus, H, Rachel, H, Barney, H, Bu, H, Emma, H, Paul, H, Tim, H, Stephen, H, Rajapandian, I, Matthew, J, Cheryl, K, Kennedy, NA, Fevronia, K, Charles, K, Bee, L, Wendy, L, Jimmy, L, Richard, L, Peter, M, Janis, M, Steven, M, John, M, Michele, M, Charles, M-A, Alistair, M, Jasbir, N, Arvind, P, Gareth, P, Rajan, P, Uday, P, Leon, P, Kathryn, P, Thomas, P, Katie, P, Richard, P, Niall, P, Mark, P, Abdul, R, Kerry, R, Dan, R, Russell, RK, Mathew, R, Suzanne, R, Judith, S, John, S, Christian, S, Irshad, S, Ian, S, Baljit, S, Ederis, S, Christopher, S, Neil, S, Adam, S, Ben, S, Taylor, SA, Julian, T, Tham, TC, Pradeep, T, John, T, Jared, T, Simon, T, Mark, T, Tracey, T, Christos, T, Carolynne, V, Oliver, W, Janindra, W, Emma, W, Debbie, W, Graham, W, Mark, W, Graeme, W, Eleanor, W, Hannah, Y, Lisa, Y |
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Přispěvatelé: | Royal College of Surgeons of England |
Rok vydání: | 2018 |
Předmět: |
PROTOCOL
0301 basic medicine Research design Delphi Technique Consensus Development Conferences as Topic Delphi method ENiGMA collaborators 0302 clinical medicine Crohn Disease Quality of life Risk Factors Outcome Assessment Health Care Medicine ANTI-TNF Response rate (survey) FISTULAS Gastroenterology TRIALS crohn’s disease Systematic review Centre for Surgical Research Research Design Disease Progression 030211 gastroenterology & hepatology Life Sciences & Biomedicine STEM-CELLS medicine.medical_specialty Likert scale Interviews as Topic Outcome Assessment (Health Care) 03 medical and health sciences Crohn Disease/pathology MANAGEMENT Rectal Fistula Humans Patient Reported Outcome Measures clinical trials Science & Technology Gastroenterology & Hepatology business.industry Inflammatory Bowel Disease Perianal Abscess ibd 1103 Clinical Sciences CARE Clinical trial 030104 developmental biology Family medicine Quality of Life 1114 Paediatrics and Reproductive Medicine Rectal Fistula/pathology anal sepsis business COSTS Fecal Incontinence Fecal Incontinence/etiology Systematic Reviews as Topic |
Zdroj: | 2019, ' Developing a core outcome set for fistulising perianal Crohn's disease ', Gut, vol. 68, no. 2, pp. 226-238 . https://doi.org/10.1136/gutjnl-2017-315503 Gut |
ISSN: | 1468-3288 0017-5749 |
Popis: | ObjectiveLack of standardised outcomes hampers effective analysis and comparison of data when comparing treatments in fistulising perianal Crohn’s disease (pCD). Development of a standardised set of outcomes would resolve these issues. This study provides the definitive core outcome set (COS) for fistulising pCD.DesignCandidate outcomes were generated through a systematic review and patient interviews. Consensus was established via a three-round Delphi process using a 9-point Likert scale based on how important they felt it was in determining treatment success culminating in a final consensus meeting. Stakeholders were recruited nationally and grouped into three panels (surgeons and radiologists, gastroenterologists and IBD specialist nurses, and patients). Participants received feedback from their panel (in the second round) and all participants (in the third round) to allow refinement of their scores.ResultsA total of 295 outcomes were identified from systematic reviews and interviews that were categorised into 92 domains. 187 stakeholders (response rate 78.5%) prioritised 49 outcomes through a three-round Delphi study. The final consensus meeting of 41 experts and patients generated agreement on an eight domain COS. The COS comprised three patient-reported outcome domains (quality of life, incontinence and a combined score of patient priorities) and five clinician-reported outcome domains (perianal disease activity, development of new perianal abscess/sepsis, new/recurrent fistula, unplanned surgery and faecal diversion).ConclusionA fistulising pCD COS has been produced by all key stakeholders. Application of the COS will reduce heterogeneity in outcome reporting, thereby facilitating more meaningful comparisons between treatments, data synthesis and ultimately benefit patient care. |
Databáze: | OpenAIRE |
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