Features of ozone effect on the oxygen-dependent blood processes under hypercapnia conditions
| Autor: | V V, Zinchuk, E S, Biletskaya, I E, Gulyai |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biomeditsinskaya Khimiya. 68:212-217 |
| ISSN: | 2310-6905 2310-6972 |
| DOI: | 10.18097/pbmc20226803212 |
| Popis: | The aim of this work is to study of ozone effect on blood oxygen-dependent processes under hypercapnia conditions. The studied blood samples are pretreated with a hypercapnic gas mixture followed by the addition of ozonized isotonic sodium chloride solution (with an ozone concentration of 6 mg/l), as well as gaseous transmitters donors, nitroglycerin and sodium hydrosulfide. It has been established that hypercapnia enhanced the ozone effect on the blood oxygen transport function and was characterized by the oxyhemoglobin dissociation curve shift to the right, also increased hydrogen sulfide synthesis and absence of changes in the nitrates/nitrites concentration. Under these conditions nitroglycerin and sodium hydrosulfide did not change the parameters of the blood gas transport function, but increased the level of nitrate/nitrite and hydrogen sulfide. Preliminary hypercapnia does not eliminate the activating effect of ozone on the free radical oxidation processes, and the addition of the applied gaseous transmitter donors does not contribute to the regulation of the studied parameters.V poslednee vremia v meditsinskoĭ praktike vse chashche ispol'zuiutsia nemedikamentoznye metody lecheniia, takie kak ozonoterapiia. Tsel'iu dannogo issledovaniia bylo izuchenie osobennosteĭ deĭstviia ozona na kislorodzavisimye protsessy krovi v usloviiakh giperkapnii. Issleduemye obraztsy krovi podvergali predvaritel'noĭ obrabotke giperkapnicheskoĭ gazovoĭ smes'iu c posleduiushchim dobavleniem ozonirovannogo izotonicheskogo rastvora khlorida natriia (s kontsentratsieĭ ozona 6 mg/l), a takzhe donorov gazotransmitterov: nitroglitserina i gidrosul'fida natriia. V étikh usloviiakh giperkapniia usilivala éffekt ozona na kislorodtransportnuiu funktsiiu krovi i vyzyvala sdvig krivoĭ dissotsiatsii oksigemoglobina vpravo i uvelichivala sintez serovodoroda pri otsutstvii izmeneniĭ kontsentratsii nitratov/nitritov. Nitroglitserin i gidrosul'fid natriia v étikh usloviiakh ne izmeniali parametry gazotransportnoĭ funktsii krovi, no povyshali uroven' nitratov/nitritov i serovodoroda. Predvaritel'naia giperkapniia ne ustraniala aktiviruiushchego deĭstviia ozona na protsessy svobodnoradikal'nogo okisleniia, takzhe kak i primenenie donorov gazotransmitterov. |
| Databáze: | OpenAIRE |
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