Combinatorial metabolism drives the naive to primed pluripotent chromatin landscape
| Autor: | Abdiasis M. Hussein, Julie Mathieu, Devon Ehnes, Hannele Ruohola-Baker, Carol B. Ware |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pluripotent Stem Cells
0301 basic medicine Cellular differentiation Gene Expression Regulation Developmental Cell Differentiation Cell Biology Metabolism Biology Chromatin Epigenesis Genetic Cell biology 03 medical and health sciences Blastocyst 030104 developmental biology 0302 clinical medicine Metabolic regulation 030220 oncology & carcinogenesis Metabolome Animals Humans Epigenetics Stem cell Embryonic Stem Cells |
| Zdroj: | Experimental Cell Research. 389:111913 |
| ISSN: | 0014-4827 |
| Popis: | Since epigenetic modifications are a key driver for cellular differentiation, the regulation of these modifications is tightly controlled. Interestingly, recent studies have revealed metabolic regulation for epigenetic modifications in pluripotent cells. As metabolic differences are prominent between naive (pre-implantation) and primed (post-implantation) pluripotent cells, the epigenetic changes regulated by metabolites has become an interesting topic of analysis. In this review we discuss how combinatorial metabolic activities drive the developmental progression through early pluripotent stages. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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