DIRECT HORMONE INACTIVATION BY EXTRACTS OF LITHOSPERMUM RUDERALE

Autor:	R. L. Noble, R. C. B. Graham, E. R. Plunkett
Rok vydání:	1954
Předmět:	endocrine system medicine.medical_specialty biology Lithospermum Endocrinology Diabetes and Metabolism biology.organism_classification Hormones Lithospermum ruderale Endocrinology Internal medicine medicine Humans Hormone
Zdroj:	Journal of Endocrinology. 10:212-227
ISSN:	1479-6805 0022-0795
DOI:	10.1677/joe.0.0100212
Popis:	SUMMARY 1. The inhibiting action of extracts of Lithospermum ruderale (lithosperm) when mixed with various hormones has been described. 2. Pituitary gonadotrophin, prolactin (luteotrophin), thyrotrophin and pregnant mares' serum gonadotrophin (PMS) are readily inactivated. Chorionic gonadotrophin is less readily affected, and pituitary growth hormone and ACTH are unaffected by the concentration of lithosperm which inactivates the other hormones. Insulin and posterior pituitary hormones are equally unaffected. 3. PMS 'inactivated' by lithosperm is still capable of causing marked interstitial cell stimulation of the ovary of the intact rat with resulting oestrogen production. Hypophysectomy abolishes this reaction. 4. Various factors influencing the in vitro inactivation have been described, so that a standard method could be developed for testing fractions obtained in purifying lithosperm extracts. 5. Some preliminary extraction methods are discussed.
Databáze:	OpenAIRE
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