Arsenic-induced epigenetic changes in cancer development
| Autor: | Yvonne N. Fondufe-Mittendorf, Wesley N. Saintilnord |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Inorganic arsenic Carcinogenesis Mechanism (biology) chemistry.chemical_element DNA Methylation Biology Disease pathogenesis Bioinformatics Article Arsenic Epigenesis Genetic 03 medical and health sciences 030104 developmental biology 0302 clinical medicine chemistry Neoplasms 030220 oncology & carcinogenesis DNA methylation Animals Humans Cancer development Epigenetics |
| Zdroj: | Semin Cancer Biol |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2021.03.019 |
| Popis: | Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to millions of people worldwide by increasing susceptibility to various cancers and non-cancer illnesses. Since arsenic is not a mutagen, the mechanism by which it causes changes in gene expression and disease pathogenesis is not clear. One possible mechanism is through generation of reactive oxygen species. Another equally important mechanism still very much in its infancy is epigenetic dysregulation. In this review, we discuss recent discoveries underlying arsenic-induced epigenetic changes in cancer development. Importantly, we highlight the proposed mechanisms targeted by arsenic to drive oncogenic gene expression. |
| Databáze: | OpenAIRE |
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