Relationship between Augmentation Index and Wall Thickening Fraction during Hypotension in an Animal Model of Myocardial Ischemia-Reperfusion and Heart Failure
| Autor: | Jorge A. Negroni, Elena C. Lascano, Sandra Wray, Edmundo I. Cabrera Fischer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cardiac output Diastole Ischemia Cardiac index Myocardial Ischemia Myocardial Reperfusion Injury Ventricular Function Left Basal (phylogenetics) Internal medicine Internal Medicine medicine Animals Heart Failure Sheep business.industry medicine.disease Disease Models Animal Heart failure Reperfusion Cardiology Aortic pressure Halothane Hypotension business medicine.drug |
| Zdroj: | Current hypertension reviews. 17(2) |
| ISSN: | 1875-6506 |
| Popis: | Aims: Non-invasive indices to evaluate left ventricular changes during ischemic heart failure are needed to quantify the myocardial impairment and the effectiveness of therapeutic manoeuvres. The aims of this work were to calculate the Wall Thickening Fraction (WTF) and the Augmentation Index (AIx) and to assess the relationship between WTF and AIx using data obtained from an animal model with heart failure followed by a myocardial ischemia stage and a reperfusion stage. Methods: Nine Corriedale sheep that had been monitored for 10 minutes during a basal stage underwent 5-minute myocardial ischemia, followed by 60-minute reperfusion. Seven of them were subjected to an induced heart failure through an overdose of halothane, two of which were treated with intra-aortic counterpulsation during the reperfusion stage. The remaining two animals were monitored during their ischemia-reperfusion stage. Results: Data obtained in the 5 animals suffering from heart failure followed by myocardial ischemia showed that: a) heart failure induction determined decrease in cardiac output, cardiac index and systolic and diastolic aortic pressure (AoP) with respect to their basal values (p Conslusion: AIx and WTF values calculated from synchronically recorded values of aortic pressure and left ventricular wall thickness during the reperfusion stage in all animals (n = 9) showed a negative correlation (p |
| Databáze: | OpenAIRE |
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