PTX3 as a potential novel tool for the diagnosis and monitoring of pulmonary fungal infections in immuno-compromised pediatric patients
| Autor: | Mariagrazia Dell'Oro, Alberto Mantovani, Marina Col, Ettore Biagi, Mario Renato Rossi, Giuseppe Peri, Alessandro Montanelli, Andrea Biondi, Maddalena Migliavacca, Daniela Silvestri |
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| Přispěvatelé: | Biagi, E, Col, M, Migliavacca, M, Dell'Oro, M, Silvestri, D, Montanelli, A, Peri, G, Mantovani, A, Biondi, A, Rossi, M |
| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary Fungal Infections Antifungal Agents Adolescent Immunocompromised Host Immunity Medicine Humans Prospective Studies Prospective cohort study Child Pediatric leukemia Lung Diseases Fungal business.industry Case-control study Infant SUPERFAMILY Hematology PTX3 Precursor Cell Lymphoblastic Leukemia-Lymphoma Immunity Innate PTX-3 fungal infections Serum Amyloid P-Component C-Reactive Protein Oncology Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Immunology Cohort Female business |
| Zdroj: | Journal of pediatric hematology/oncology. 30(12) |
| ISSN: | 1536-3678 |
| Popis: | Pentraxin-3 (PTX3) is a member of the long pentraxin superfamily and has a nonredundant role in mediating resistance to fungal pathogens. Serial monitoring of PTX3 plasmatic levels was performed in 10 pediatric leukemia patients affected by pulmonary fungal infections. When compared with values of a control pediatric cohort, PTX3 showed significantly higher plasmatic values. Moreover, the response to the antifungal therapy correlated with normalization of PTX3 values. PTX3 may represent a useful tool for the diagnosis and monitoring of fungal infections in immuno-compromised children. |
| Databáze: | OpenAIRE |
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