Elevated serum fibrinogen level is an independent risk factor for IgA nephropathy
| Autor: | Qiongxiu Zhou, Chaosheng Chen, Min Pan, Jianna Zhang, Zhanyuan Li, Ji Zhang, Xiaohan You, Shubei Zheng, Zhihong Zhou, Yinqiu Lv |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Nephrology medicine.medical_specialty Pathology 030232 urology & nephrology urologic and male genital diseases Fibrinogen Gastroenterology Nephropathy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Renal fibrosis renal outcome Kidney medicine.diagnostic_test business.industry Oxford classification IgA nephropathy medicine.disease 030104 developmental biology Elevated serum creatinine medicine.anatomical_structure Oncology fibrinogen Renal biopsy Clinical Research Paper business chronic kidney disease Kidney disease medicine.drug |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.21702 |
| Popis: | // Ji Zhang 2 , Chaosheng Chen 2 , Qiongxiu Zhou 2 , Shubei Zheng 1 , Yinqiu Lv 2 , Jianna Zhang 2 , Xiaohan You 2 , Zhanyuan Li 1 , Zhihong Zhou 1 and Min Pan 1 1 Department of Nephrology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China 2 Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China Correspondence to: Min Pan, email: pm_1234@163.com Keywords: IgA nephropathy, fibrinogen, chronic kidney disease, Oxford classification, renal outcome Received: July 29, 2017 Accepted: September 22, 2017 Published: October 09, 2017 ABSTRACT Background: IgA nephropathy is a primary cause of renal failure, and inflammation and renal fibrosis are the main mechanisms leading to kidney damage. The serum fibrinogen level is closely related to inflammatory states, but its relationship to the prognosis of IgA nephropathy (IgAN) is unclear. Materials and Methods: 1053 patients diagnosed with IgAN after renal biopsy were enrolled from two Nephrology Departments. Demographic and clinical data and histopathological features were collected. The patients were divided into four groups (Q1–Q4) according to the serum fibrinogen levels at the time of renal biopsy, and the relationships of serum fibrinogen levels with other risk factors and the prognosis of IgAN were investigated. Results: 672 patients with proven primary IgAN were included in this study, which included a median follow-up of 36 months. Patients with higher serum fibrinogen levels had elevated serum creatinine levels, 24-hour urinary protein, and blood pressure compared with patients with the lowest levels of serum fibrinogen as well as severe renal damage at the time of renal biopsy. Univariate and multivariate Cox regression analyses confirmed that the serum fibrinogen level at the time of renal biopsy was significantly related to the prognosis of patients with IgAN. Conclusions: In patients with IgAN, an elevated serum fibrinogen level at the time of renal biopsy is associated with poor renal outcomes, which suggests the need for more aggressive early interventions. Greater benefits of aggressive treatments were observed in patients with higher serum fibrinogen levels. |
| Databáze: | OpenAIRE |
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