Bone fractures and lumbar mineral density after renal transplantation. A long-term cross-sectional study

Autor:	Carlos Quereda, C. Caballero, José L. Teruel, Sara Jiménez, Juan José Villafruela, Ana Fernández-Rodríguez, Cristina Galeano, Carlos Vaamonde, Roberto Marcén
Rok vydání:	2016
Předmět:	Adult Graft Rejection Male medicine.medical_specialty Adolescent Bone density Osteoporosis Population 030232 urology & nephrology Lumbar vertebrae 030230 surgery Kidney Function Tests Fractures Bone Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Bone Density Risk Factors medicine Humans education Aged Retrospective Studies Femoral neck Transplantation education.field_of_study Lumbar Vertebrae Trochanter business.industry Graft Survival Middle Aged Prognosis medicine.disease Kidney Transplantation Surgery Osteopenia Cross-Sectional Studies medicine.anatomical_structure Kidney Failure Chronic Female business Follow-Up Studies Glomerular Filtration Rate
Zdroj:	Clinical Transplantation. 30:131-137
ISSN:	0902-0063
Popis:	Background The purpose of this work was to investigate the association of vertebral and peripheral fractures 10 yr after grafting with bone metabolic markers and body mass density (BMD). Patients and methods One hundred thirty-eight recipients with stable graft function were included in a cross-sectional study. Graft function, biochemical mineral metabolism markers and body mass density (DEXA) were measured. Vertebral fractures were assessed by a semiquantitative analysis of lateral spine X-ray exam. Results At the time of the study, intact parathyroid hormone levels were 127.5 ± 78.4 pg/mL and serum calcidiol 20.4 ± 9.3 ng/mL. DEXA showed osteopenia in 47% and osteoporosis in 23% at lumbar spine, 51% and 14% at femoral neck, and 53% and 8% at trochanter. Eighty-five recipients presented vertebral fractures, 69 mild and 16 moderate/severe fractures. In the multivariate analysis, vertebral fractures were associated with older age (p = 0.010), length of follow-up (p = 0.022) and trochanter T-score (p = 0.038). Twenty-three patients presented peripheral fractures and 19 of them also had vertebral fractures. Patients with peripheral fractures were younger, mostly women and had lower BMD. Conclusions Vertebral fractures were associated with lower BMD at trochanter. Most fractures were mild and were several times more frequent than in general population. Their clinical significance needs to be determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207bd4fe2a1e88c0b874c15274e33ce4 https://doi.org/10.1111/ctr.12666 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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