Subclinical hypothyroidism in danish lean and obese children and adolescents

Autor: Maria Dahl, Cilius Esmann Fonvig, Jens-Christian Holm, Johanne Dam Ohrt, Oluf Pedersen, Julie T. Kloppenborg, Torben Hansen
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Pediatrics
Thyrotropin/blood
Cross-sectional study
Thyroid hormones
Denmark
Endocrinology
Diabetes and Metabolism
Thyrotropin
Overweight
Body Mass Index
Thyroxine/blood
0302 clinical medicine
Endocrinology
Prevalence
Registries
030212 general & internal medicine
Childhood obesity
Child
Subclinical infection
Waist-to-height ratio
Registries/statistics & numerical data
Hypothyroidism/blood
Triiodothyronine
Original Article
Female
medicine.symptom
Waist Circumference
medicine.medical_specialty
Triiodothyronine/blood
Adolescent
Overweight/blood
030209 endocrinology & metabolism
03 medical and health sciences
Hypothyroidism
medicine
Humans
Obesity
thyroid hormones
business.industry
Body Weight
nutritional and metabolic diseases
Waist-height ratio
Anthropometry
medicine.disease
Denmark/epidemiology
Thyroxine
Obesity/blood
Cross-Sectional Studies
waist-height ratio
Pediatrics
Perinatology and Child Health
Linear Models
business
Body mass index
Zdroj: Dahl, M, Ohrt, J D, Fonvig, C E, Kloppenborg, J T, Pedersen, O, Hansen, T & Holm, J C 2017, ' Subclinical hypothyroidism in danish lean and obese children and adolescents ', JCRPE Journal of Clinical Research in Pediatric Endocrinology, vol. 9, no. 1, pp. 8-16 . https://doi.org/10.4274/jcrpe.3319
Journal of Clinical Research in Pediatric Endocrinology
DOI: 10.4274/jcrpe.3319
Popis: Objective: Thyroid abnormalities are common in obese children. The aim of the present study was to examine the prevalence of subclinical hypothyroidism (SH) and to determine how circulating thyroid hormone concentrations correlate with anthropometrics in Danish lean and obese children and adolescents. Methods: In this cross-sectional study, we included 3006 children and adolescents, aged 6-18 years, from the Registry of the Danish Childhood Obesity Biobank. The overweight/obese group (n=1796) consisted of study participants with a body mass index (BMI) standard deviation score (SDS) ≥1.28. The control group (n=1210) comprised lean children with a BMI SDS 4) at baseline. Results: The prevalence of SH was higher among overweight/obese compared to lean study participants (10.4% vs. 6.4%, p=0.0001). In the overweight/obese group, fasting serum TSH concentrations were associated positively with BMI SDS (p4 concentrations were associated positively only with WHtR. The odds ratio of exhibiting SH was 1.8 when being overweight/obese compared with lean (p=0.0007) and 1.8 when presenting with a WHtR >0.5 (p=0.0003). Conclusion: The prevalence of SH was higher among overweight/obese study participants. The positive correlations of circulating TSH and fT4 with WHtR suggest that central obesity, independent of the overall degree of obesity, augments the risk of concurrent thyroid abnormalities in children and adolescents with obesity.
Databáze: OpenAIRE
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