Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia
| Autor: | Yu. S. Kisrieva, N. A. Petushkova, G P Kuznetsova, I. I. Karuzina, N. F. Samenkova, O. V. Larina, V. G. Zgoda, D U Usachev, N B Teryaeva, A. Yu. Belyaev |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Proteome Angiogenesis Cellular differentiation medicine.medical_treatment Ischemia General Biochemistry Genetics and Molecular Biology Mass Spectrometry Brain Ischemia 03 medical and health sciences 0302 clinical medicine Blood plasma Fibrinolysis medicine Humans Cytoskeleton Aged Chemistry General Medicine Blood Proteins Cerebral Infarction Middle Aged medicine.disease Cell biology 030104 developmental biology Female 030217 neurology & neurosurgery Homeostasis Chromatography Liquid |
| Zdroj: | Bulletin of experimental biology and medicine. 165(1) |
| ISSN: | 1573-8221 |
| Popis: | Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink