Distortion of micronuclei and other peripheral erythrocytes caused by fenitrothion and their recovery assemblage in zebrafish
| Autor: | Mt. Marufa Khatun, M. Sadiqul Islam, Golam Mohammod Mostakim, Md. Moniruzzaman, Umme Ohida Rahman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Health
Toxicology and Mutagenesis Environmental pollution 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Fenitrothion Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Organophosphate RA1190-1270 Recuperation medicine Zebrafish 0105 earth and related environmental sciences ComputingMethodologies_COMPUTERGRAPHICS Acute toxicity biology Chemistry Regular Article Biomarker biology.organism_classification Erythrocytic abnormalities Micronucleus test Toxicology. Poisons Genotoxicity Micronucleus 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports, Vol 8, Iss, Pp 415-421 (2021) Toxicology Reports |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • Genotoxic effects of fenitrothion in the erythrocytes of zebrafish was measured. • Abnormality of erythrocyte were found to be raised after the exposure of fenitrothion. • Abnormality of erythrocyte recovered with a concentration-and duration-dependent way. • Fish erythrocyte is an effective biomarker for toxicity test of an organophosphate. The experiment was explicated to investigate the fenitrothion persuaded genotoxicity in the peripheral erythrocytes of zebrafish (Danio rerio) through in vivo exposures (10 %, 20 % and 40 % of LC50 of fenitrothion, i.e., 0.8, 1.6, and 3.2 mg/L, respectively) for variable periods (1, 3, and 7 days) and its subsequent post-exposure recuperation array in pesticide-free water for similar intervals was also evaluated. With the exception of the control group (0% of fenitrothion), the obtained results pointed out that with the promotion of time and concentrations, fenitrothion induced significantly (p < 0.05) higher prevalence and severity of erythrocytic nuclear abnormalities (ENA) such as- notched, micronucleus, nuclear bridges, blebbed, binucleated, nuclear bud and also erythrocytic cellular abnormalities (ECA) such as - echinocytic, elongated, tear-drop, crescentic, twin, fusion, and spindle-shaped cells. Recuperation data stated that zebrafish cured spontaneously and aberrated erythrocytic anomalies in all treatments were renormalized according to the concentration and duration dependence. Hence, we concluded that fenitrothion has a dangerous effect on the zebrafish, and this technology can be used to anticipate the sensitivity of aquatic animals to environmental pollution. |
| Databáze: | OpenAIRE |
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