Trimethoprim-sulfamethoxazole Versus Azithromycin for the Treatment of Undifferentiated Febrile Illness in Nepal: A Double-blind, Randomized, Placebo-controlled Trial
| Autor: | Sunil Pokharel, Kamal Lamsal, Abhilasha Karkey, Guy E. Thwaites, Rabi Prakash Sharma, Sita Ram Shrestha, Saruna Pathak, Amit Arjyal, Buddha Basnyat, Buddhi Poudyal, Sujata Pandey, Sabina Dangol, Dung Nguyen Thi Phuong, Stephen Baker, Ronald B. Geskus, Damodar Gajurel, Gayatri Prajapati, Raj Kumar K C, Pradip Shrestha, Nistha Shrestha, Evelyne Kestelyn, Abhishek Giri, Raj Kumar Thapa, Samita Rijal, Abishkar Thapa |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Fever Nausea Placebo-controlled study South Asia Azithromycin Typhoid fever Internal medicine Clinical endpoint health economics Humans Medicine Online Only Articles Adverse effect business.industry medicine.disease Trimethoprim Major Articles and Commentaries AcademicSubjects/MED00290 Infectious Diseases Scrub Typhus Vomiting medicine.symptom business typhoid fever medicine.drug |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Azithromycin and trimethoprim-sulfamethoxazole (SXT) are widely used to treat undifferentiated febrile illness (UFI). We hypothesized that azithromycin is superior to SXT for UFI treatment, but the drugs are noninferior to each other for culture-confirmed enteric fever treatment. Methods We conducted a double-blind, randomized, placebo-controlled trial of azithromycin (20 mg/kg/day) or SXT (trimethoprim 10 mg/kg/day plus sulfamethoxazole 50 mg/kg/day) orally for 7 days for UFI treatment in Nepal. We enrolled patients >2 years and We compared azithromycin with trimethoprim-sulfamethoxazole for 7 days in the treatment of undifferentiated febrile illness in Nepal. Despite similar fever clearance time and treatment failure in the 2 arms, significantly fewer complications and relapses were noted in the azithromycin arm. |
| Databáze: | OpenAIRE |
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