Benchmarking the ACEnano Toolbox for Characterisation of Nanoparticle Size and Concentration by Interlaboratory Comparisons
| Autor: | Ruud Peters, Ingrid Elbers, Anna Undas, Eelco Sijtsma, Sophie Briffa, Pauline Carnell-Morris, Agnieszka Siupa, Tae-Hyun Yoon, Loïc Burr, David Schmid, Jutta Tentschert, Yves Hachenberger, Harald Jungnickel, Andreas Luch, Florian Meier, Jovana Kocic, Jaeseok Kim, Byong Park, Barry Hardy, Colin Johnston, Kerstin Jurkschat, Jörg Radnik, Vasile-Dan Hodoroaba, Iseult Lynch, Eugenia Valsami-Jones |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
analysis nanomaterials benchmarking interlaboratory comparison Pharmaceutical Science Nanoparticle Organic chemistry Nanomaterials Analysis Benchmarking Interlaboratory comparison Nanotechnology 02 engineering and technology 01 natural sciences Article Analytical Chemistry QD241-441 Drug Discovery Laboratorium voor Plantenfysiologie Physical and Theoretical Chemistry Sunscreen lotion Team Organic Contaminants Complex matrix Team Animal Drugs 1 010401 analytical chemistry Nanostructured materials 021001 nanoscience & nanotechnology Aqueous suspension 0104 chemical sciences Team Pesticides 1 Chemistry (miscellaneous) Molecular Medicine Particle Nanoparticles Particle size EPS 0210 nano-technology Laboratories Laboratory of Plant Physiology |
| Zdroj: | Molecules, Vol 26, Iss 5315, p 5315 (2021) Molecules, 26(17) Molecules Molecules 26 (2021) 17 Molecules; Volume 26; Issue 17; Pages: 5315 Molecules, 26 (17) |
| ISSN: | 1420-3049 |
| Popis: | ACEnano is an EU-funded project which aims at developing, optimising and validating methods for the detection and characterisation of nanomaterials (NMs) in increasingly complex matrices to improve confidence in the results and support their use in regulation. Within this project, several interlaboratory comparisons (ILCs) for the determination of particle size and concentration have been organised to benchmark existing analytical methods. In this paper the results of a number of these ILCs for the characterisation of NMs are presented and discussed. The results of the analyses of pristine well-defined particles such as 60 nm Au NMs in a simple aqueous suspension showed that laboratories are well capable of determining the sizes of these particles. The analysis of particles in complex matrices or formulations such as consumer products resulted in larger variations in particle sizes within technologies and clear differences in capability between techniques. Sunscreen lotion sample analysis by laboratories using spICP-MS and TEM/SEM identified and confirmed the TiO2 particles as being nanoscale and compliant with the EU definition of an NM for regulatory purposes. In a toothpaste sample orthogonal results by PTA, spICP-MS and TEM/SEM agreed and stated the TiO2 particles as not fitting the EU definition of an NM. In general, from the results of these ILCs we conclude that laboratories are well capable of determining particle sizes of NM, even in fairly complex formulations. Molecules, 26 (17) ISSN:1420-3049 |
| Databáze: | OpenAIRE |
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