The Reversed Clock Drawing Test Phenomenon in Alzheimer’s Disease: A Perfusion SPECT Study
| Autor: | P Barbieri, P. M. Koulibaly, G Cabassi, Debora Mazzei, Andrea Brugnolo, Gianmario Sambuceti, Guido Rodriguez, Barbara Dessi, Nicola Girtler, Francesco Famà, Silvia Morbelli, Flavio Nobili |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Neuropsychological Tests Single-photon emission computed tomography Apraxia Central nervous system disease Executive Function Degenerative disease Radionuclide angiography Alzheimer Disease Internal medicine medicine Humans Radionuclide Angiography Aged Retrospective Studies Psychiatric Status Rating Scales Tomography Emission-Computed Single-Photon medicine.diagnostic_test Depression Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Cerebrovascular Circulation Cardiology Female Geriatrics and Gerontology Alzheimer's disease Psychology Perfusion Neuroscience |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 29:1-10 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000270898 |
| Popis: | Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer’s disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD–) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD– versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|